Delay- and Pressure-Dependent Neuromodulatory Effects of Transcranial Ultrasound Stimulation

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2025-04-01 DOI:10.1016/j.neurom.2025.01.004

Cyril Atkinson-Clement PhD , Mohammad Alkhawashki MSc , Marilyn Gatica PhD , Stefanos Alexandros Kontogouris MSc , Marcus Kaiser PhD

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引用次数: 0

Abstract

Objective

Despite the growing interest in transcranial focused ultrasound stimulation (TUS), our understanding of its underlying mechanisms remains limited. In this study, we aimed to investigate the effects of TUS on several functional magnetic resonance imaging metrics by considering their latency, duration, and relationship with applied acoustic pressure.

Materials and methods

We recruited 22 healthy volunteers and used a pre- vs post-TUS protocol. Half of the volunteers were stimulated in the right inferior frontal cortex and the other half in the right thalamus. The fractional amplitudes of low-frequency fluctuations, regional homogeneity, degree centrality, local functional connectivity density, and eigenvector centrality were considered. These metrics were compared before TUS and at three different time points in the first hour after TUS.

Results

Our results showed that 1) TUS primarily alters functional connectivity metrics at both the local and global levels; 2) stronger alterations are observed when the delay after TUS increases and 3) when the applied acoustic pressure is close to the maximum.

Conclusion

These results suggest that some consequences of TUS might not be immediate, inviting us to revise the premise that TUS consequences are immediate and will progressively disappear.

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来源期刊

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.