{"title":"Understanding the biochemistry of hormones - message in a bottle.","authors":"Dominic C Y Lai, Jonathan Wolf Mueller","doi":"10.1042/EBC20240039","DOIUrl":null,"url":null,"abstract":"<p><p>Hormones play pivotal roles in our well-being, and even more so in times of stress or disease. They determine body composition and govern reproductive processes. Hormonal compounds tend to be evolutionarily very old compounds, but only coevolved receptor systems make up powerful biological signals. We will discuss what makes some metabolites good building materials for hormones and how information may be encoded, using these scaffolds. Starting with hormone biosynthesis and regulated release from secreting cells, we will look at different stages of the whole hormone signaling process: the distribution of the hormonal \"message-in-a-bottle\" throughout the body, the passing of some hormones through membranes, and pre-receptor metabolism. Binding to different classes of receptors is not the end of hormone signaling, but the beginning of a second phase of signaling via second messengers, before hormonal messages are switched off again. Studying hormone biochemistry will produce exciting new findings in the future.</p>","PeriodicalId":11812,"journal":{"name":"Essays in biochemistry","volume":"69 1","pages":"1-18"},"PeriodicalIF":5.6000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Essays in biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1042/EBC20240039","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Hormones play pivotal roles in our well-being, and even more so in times of stress or disease. They determine body composition and govern reproductive processes. Hormonal compounds tend to be evolutionarily very old compounds, but only coevolved receptor systems make up powerful biological signals. We will discuss what makes some metabolites good building materials for hormones and how information may be encoded, using these scaffolds. Starting with hormone biosynthesis and regulated release from secreting cells, we will look at different stages of the whole hormone signaling process: the distribution of the hormonal "message-in-a-bottle" throughout the body, the passing of some hormones through membranes, and pre-receptor metabolism. Binding to different classes of receptors is not the end of hormone signaling, but the beginning of a second phase of signaling via second messengers, before hormonal messages are switched off again. Studying hormone biochemistry will produce exciting new findings in the future.
期刊介绍：
Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic.
Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points.
Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place.
Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.
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