Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.

IF 2.3 3区医学 Q2 ANESTHESIOLOGY

BMC Anesthesiology Pub Date : 2025-02-06 DOI:10.1186/s12871-025-02930-5

Shuo Ding, Juan Chen, Yanchao Wu, Huiru Lin, Qiqiang Liang, Gaoqin Teng, Zhenjie Liu, Man Huang

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引用次数: 0

Abstract

Background: Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations.

Methods: Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis.

Results: All ten sheep survived to their planned endpoints under awake ECMO, exhibiting stable vital signs without notable reductions in blood cells. With the support of ECMO, all sheep demonstrated a significant increase in partial pressure of oxygen (PO₂) and maintained oxygen saturation (SO₂) between 99.8 and 100%. The heparin coating remained relatively intact even after prolonged ECMO operation. Anatomical observations and pathological histology analyses of major organs revealed no apparent abnormalities.

Conclusions: In healthy Hu sheep models with different maintenance periods, the novel ECMO support in awake state demonstrated high safety and feasibility.

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一种新型体外膜氧合系统在不同醒时湖羊体内的应用。

背景：体外膜氧合（ECMO）为呼吸和循环功能提供了有效的支持，是治疗危及生命的疾病的重要手段。本研究旨在评估一种新型ECMO系统在不同支持时间清醒绵羊模型中的安全性和有效性。方法：将10只健康湖羊分为静脉静脉组（VV）和静脉动脉组（VA），再分为短期、中期和长期观察亚组。严密监测生命体征和血液指标。在指定的时间点评估ECMO系统中肝素涂层的完整性和血栓形成，然后进行组织病理学分析。结果：所有10只羊在清醒ECMO下均存活至计划终点，生命体征稳定，血细胞未明显减少。在ECMO的支持下，所有绵羊的氧分压（PO2）均显著升高，氧饱和度（SO2）维持在99.8 ~ 100%之间。肝素包被即使在长时间ECMO手术后仍然保持相对完整。解剖观察及主要脏器病理组织学分析未见明显异常。结论：在不同维持周期的健康湖羊模型中，新型清醒状态ECMO支持具有较高的安全性和可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Anesthesiology ANESTHESIOLOGY-

CiteScore

3.50

自引率

4.50%

发文量

349

审稿时长

>12 weeks

期刊介绍： BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.