Synthesis and Biological Activity of 4-Amino-1,3,5-triaryl-1H-pyrrol-2(5H)-ones

Abstract

A series of 4-amino-1,3,5-triaryl-1H-pyrrol-2(5H)-ones have been synthesized by acylation of aryl­acetonitriles with arylacetyl chlorides, followed by intramolecular cyclization in the presence of potassium hydroxide. The synthesized compounds have been evaluated for their antibacterial and antitumor activities; among them, derivatives containing alkyl and alkoxy groups in the aryl fragments at positions 1, 3, and 5 of the pyrrole ring turned out to be the most active.