Design, synthesis, crystal structure and spectral characterization of copper(II) complexes of the heterocyclic aroylhydrazones: Antimicrobial and antitubercular activity studies

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-01-28 DOI:10.1016/j.ica.2025.122568

Ganesh S. Hegde , Satish S. Bhat , Sabiha Shaikh , Vinayak Kamat , Vidyanand K. Revankar

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引用次数: 0

Abstract

The ligands N′-[(E)-(furan-2-yl)methylidene]-2-hydroxy-3,5-di-tert-butyl-benzohydrazide (HL¹), N′-[(E)-(pyrol-2-yl)methylidene]-2-hydroxy-3,5-di-tert-butyl-benzohydrazide (HL²), 2-hydroxy-3,5-di-tert-butyl-N′-[(E)-(thiophen-2-yl)methylidene]benzohydrazide (HL³) and their Cu(II) complexes were synthesized. The ligands and their complexes were characterized by various spectro-analytical techniques including IR, ¹H NMR, ¹³C NMR, EPR, electronic spectroscopy, and elemental analysis. The molecular structures of HL³ and [Cu^II(L¹)₂] (1) were unambiguously established using single-crystal X-ray structure determination. All the synthesized compounds were evaluated for the antimicrobial and antitubercular activities. The antimicrobial activity of ligands and complexes 1–3 against S. aureus microorganisms was investigated. The complexes have good antimicrobial activity with low MIC values of 0.4 μg/mL in comparison with control Ciprofloxacin (2 μg/mL). The complexes 1–3 exhibited quite promising low MIC values ranging from 3.12 to 1.6 μg/mL.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.