Nickel-Catalyzed Electroreductive Sulfuration of Alkyl Alcohols with Pyridyl Thioesters

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-27 DOI:10.1021/acs.orglett.4c0466510.1021/acs.orglett.4c04665

Lingling Deng, Ying Lin, Xinxin Shao* and Yang Ye*,

引用次数: 0

Abstract

We demonstrate here an efficient and facile Ni-catalyzed electrochemical cross-electrophile thiolation approach for readily available alkyl alcohols with pyridyl thioesters. This C(sp³)–S bond-forming modular strategy displays extensive substrate adaptability and good functional group tolerance, which allows the production of a range of alkyl sulfides with specific chemoselectivity. Furthermore, the potential applications of this methodology are illustrated by last-stage modification of bioactive molecules and sulfinylative cross-couplings. Preliminary mechanistic experiments support a radical process.

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镍催化烷基醇与吡啶基硫酯的电还原硫化反应

我们在这里展示了一种高效和简便的镍催化的电化学交叉亲电硫基化方法，用于制备烷基醇和吡啶基硫酯。这种C(sp3) -S键形成的模块化策略具有广泛的底物适应性和良好的官能团耐受性，可以生产一系列具有特定化学选择性的烷基硫化物。此外，该方法的潜在应用是通过生物活性分子的最后阶段修饰和亚砜化交叉偶联来说明的。初步的机械实验支持一个激进的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.