Site-Selective Remote C4 Amination of 1-Naphthamides via Palladium–Single-Electron Transfer Catalysis

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-07 DOI:10.1021/acs.orglett.4c04858

Chandrasekaran Sivaraj, Sukumar Pradhan, Thirumanavelan Gandhi, Debabrata Maiti

引用次数: 0

Abstract

Achieving site-selective remote C–H amination of polycyclic aromatic hydrocarbons is a challenging yet exciting goal. Herein, we report the remote C4 amination of electron-deficient 1-naphthamides through a single-electron transfer strategy. This protocol features excellent functional group compatibility and does not require a chelating auxiliary.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.