Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China.

IF 0.9 4区 医学
Texas Heart Institute Journal Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI:10.14503/THIJ-24-8393
Yun Zhou, Mei Chen, Wenting Gao, Yu Chen, Ying Meng
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引用次数: 0

Abstract

Background: The impact of coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) on long-term health-related quality of life (HRQOL) in children has not been well documented.

Methods: This study investigated long-term HRQOL in a large sample of children diagnosed with KD-related CAAs. A case-control, retrospective study included 66 patients with KD-related CAAs. A total of 98 hospitalized patients were matched as controls based on age and sex: 49 patients were allocated to a group with pneumonia and 49 patients were allocated to a group with arterio-arterial fistula. Both child-reported and parent-proxy-reported Pediatric Quality of Life Inventory surveys were collected.

Results: The median (IQR) follow-up period was 5.64 (3.81-7.47) years (range, 1.03-10.67 years). The mean (SD) age at diagnosis was 3.73 (1.93) years. At baseline, children and parents as their proxies reported similar HRQOL scores for KD-related CAAs and arterio-arterial fistula that were considerably lower than for pneumonia, respectively. At long-term follow-up, children in the small and medium-sized aneurysms group reported a mean (SD) score of 81.61 (19.50), which was comparable to the arterio-arterial fistula group (83.32 [18.24]), 9.51 points lower than that of the pneumonia group (P = .014), and 9.70 points higher than that of the giant aneurysms group (P = .012). Parents also reported a comparable mean (SD) score of 81.03 (12.57) vs 83.30 (15.17) in the small and medium-sized aneurysms group and arterio-arterial fistula group, both of which had statistically significantly lower scores than the pneumonia group (P = .010) and higher scores than the giant aneurysms group (P = .009).

Conclusion: Despite improvement in HRQOL scores, children with documented KD-related CAAs without complete recovery often encountered issues that disrupted their well-being during long-term follow-up. Routine outpatient HRQOL screening could be instituted to help eliminate the risk of long-term disability following initial clinical improvement.

背景:川崎病(KD)引起的冠状动脉动脉瘤(CAAs)对儿童长期健康相关生活质量(HRQOL)的影响尚未有很好的文献记载。方法:本研究调查了大量诊断为kd相关CAAs的儿童的长期HRQOL。一项病例对照、回顾性研究纳入66例kd相关CAAs患者。根据年龄和性别,共有98名住院患者作为对照:49名患者被分配到肺炎组,49名患者被分配到动脉-动脉瘘组。收集了儿童报告和家长代理报告的儿童生活质量问卷调查。结果:中位(IQR)随访时间为5.64(3.81 ~ 7.47)年(1.03 ~ 10.67年)。诊断时的平均(SD)年龄为3.73(1.93)岁。在基线时,儿童和家长作为他们的代理报告了与kd相关的CAAs和动脉-动脉瘘相似的HRQOL评分,分别远低于肺炎。在长期随访中,中小动脉瘤组患儿的平均(SD)评分为81.61分(19.50分),与动-动脉瘘组(83.32分[18.24])相当,比肺炎组低9.51分(P = 0.014),比巨动脉瘤组高9.70分(P = 0.012)。中小动脉瘤组和动动脉瘘组的SD评分分别为81.03分(12.57分)和83.30分(15.17分),均低于肺炎组(P = 0.010),高于巨动脉瘤组(P = 0.009)。结论:尽管HRQOL评分有所改善,但未完全康复的记录为kd相关caa的儿童在长期随访中经常遇到影响其健康的问题。常规门诊HRQOL筛查可以帮助消除初步临床改善后长期残疾的风险。
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来源期刊
Texas Heart Institute Journal
Texas Heart Institute Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
自引率
11.10%
发文量
131
期刊介绍: For more than 45 years, the Texas Heart Institute Journal has been published by the Texas Heart Institute as part of its medical education program. Our bimonthly peer-reviewed journal enjoys a global audience of physicians, scientists, and healthcare professionals who are contributing to the prevention, diagnosis, and treatment of cardiovascular disease. The Journal was printed under the name of Cardiovascular Diseases from 1974 through 1981 (ISSN 0093-3546). The name was changed to Texas Heart Institute Journal in 1982 and was printed through 2013 (ISSN 0730-2347). In 2014, the Journal moved to online-only publication. It is indexed by Index Medicus/MEDLINE and by other indexing and abstracting services worldwide. Our full archive is available at PubMed Central. The Journal invites authors to submit these article types for review: -Clinical Investigations- Laboratory Investigations- Reviews- Techniques- Coronary Anomalies- History of Medicine- Case Reports/Case Series (Submission Fee: $70.00 USD)- Images in Cardiovascular Medicine (Submission Fee: $35.00 USD)- Guest Editorials- Peabody’s Corner- Letters to the Editor
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