Changes in the serum phospholipid profile of neuroborreliosis patients, foresters, and patients subjected to long-term therapy according to ILADS methods

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators Pub Date : 2025-02-03 DOI:10.1016/j.prostaglandins.2025.106966

Wojciech Łuczaj , Anna Moniuszko-Malinowska , Monika Groth , Elżbieta Skrzydlewska

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Abstract

The aim of the study was the assessment of changes in the serum phospholipid profile patients with Lyme neuroborreliosis (NB), asymptomatic people after frequent tick bites and patients after long-term multidrug therapy against B.burgdorferi. LC-QTOF-MS/MS platform was used to identify changes in serum phospholipid profile of 37 persons. The results demonstrate differences PL profile among patients with Lyme borreliosis (LB), people frequently exposed to tick bites and patients treated with long-term multidrug therapy compared to healthy subjects. Significant differences in SM, LPC, PI, and PC content of NB patients discriminate this group of patients from the other groups, have potential diagnostic value, and can be used for the development of more effective diagnostic tools. The finding that the phospholipid profile of foresters is similar to healthy people, suggests the existence of adaptive mechanisms that are currently difficult to explain but are interesting from the perspective of future research.

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根据ILADS方法，神经螺旋体病患者、林业人员和接受长期治疗的患者血清磷脂谱的变化。

本研究的目的是评估莱姆病神经螺旋体病（NB）患者、频繁蜱叮咬后无症状人群和长期多药治疗伯氏疏螺旋体患者血清磷脂谱的变化。采用LC-QTOF-MS/MS平台对37人血清磷脂谱的变化进行了分析。结果表明，莱姆病borreliosis （LB）患者、经常接触蜱虫叮咬的人以及长期接受多种药物治疗的患者的PL谱与健康受试者相比存在差异。NB患者的SM、LPC、PI、PC含量存在显著差异，可将本组患者与其他组区分开来，具有潜在的诊断价值，可用于开发更有效的诊断工具。林农的磷脂谱与健康人相似的发现表明，目前难以解释的适应性机制的存在，但从未来研究的角度来看是有趣的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.