Respiratory support in patients with Down syndrome: a systematic review.

IF 9 1区 医学 Q1 RESPIRATORY SYSTEM
European Respiratory Review Pub Date : 2025-02-05 Print Date: 2025-01-01 DOI:10.1183/16000617.0070-2024
Paolo Ruggeri, Sara Manti, Alessandra Li Pomi, Federica Lo Bello, Giorgio Morana, Claudia Profazio, Mina Bushra, Antonio Esquinas
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引用次数: 0

Abstract

Background: The population with Down syndrome (DS) makes up a significant portion of patients using short- and long-term noninvasive ventilation (NIV). However, limited data are available concerning the use and outcomes for patients with DS compared with other populations. We systematically reviewed articles providing indications, benefits, adherence and limits of long-term NIV use in the paediatric and adult population with DS.

Methods: A systematic review of the literature for articles published between January 2013 and November 2023 was conducted using a protocol registered at PROSPERO (CRD42023488712).

Results: In total, 18 studies focusing on the use of noninvasive respiratory support in patients with DS were included in this review. Obstructive sleep apnoea syndrome (OSAS), OSAS post-adenotonsillectomy, hypoventilation and nocturnal hypercapnia were the most common indications for NIV support in patients with DS. However, respiratory anatomical malformation and intellectual disabilities can affect adherence to NIV use. High-flow nasal cannula is an alternative to other noninvasive respiratory support.

Conclusion: Comprehensive and updated consensus compliant with international standards for clinical guidelines is required to significantly improve clinical practice quality, promote evidence-based recommendations and provide tailored interventions in patients with DS.

唐氏综合征患者的呼吸支持:一项系统综述。
背景:唐氏综合征(DS)患者在使用短期和长期无创通气(NIV)的患者中占很大比例。然而,与其他人群相比,关于退行性椎体滑移患者的使用和结果的数据有限。我们系统地回顾了提供儿童和成人DS患者长期使用NIV的适应症、益处、依从性和局限性的文章。方法:采用在PROSPERO注册的方案(CRD42023488712)对2013年1月至2023年11月发表的文献进行系统综述。结果:本综述共纳入18项关于退行性椎体滑移患者使用无创呼吸支持的研究。阻塞性睡眠呼吸暂停综合征(OSAS)、腺扁桃体切除术后的OSAS、低通气和夜间高碳酸血症是退行性椎体滑移患者支持NIV的最常见适应症。然而,呼吸解剖畸形和智力残疾会影响坚持使用NIV。高流量鼻插管是其他无创呼吸支持的替代方法。结论:为了显著提高临床实践质量,促进循证建议,并为退行性椎体滑移患者提供量身定制的干预措施,需要全面且符合国际临床指南标准的最新共识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Respiratory Review
European Respiratory Review Medicine-Pulmonary and Respiratory Medicine
CiteScore
14.40
自引率
1.30%
发文量
91
审稿时长
24 weeks
期刊介绍: The European Respiratory Review (ERR) is an open-access journal published by the European Respiratory Society (ERS), serving as a vital resource for respiratory professionals by delivering updates on medicine, science, and surgery in the field. ERR features state-of-the-art review articles, editorials, correspondence, and summaries of recent research findings and studies covering a wide range of topics including COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis, and pulmonary infections. Articles are published continuously and compiled into quarterly issues within a single annual volume.
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