A highly efficient and magnetically separable Fe3O4@CeO2 nanoparticles for the catalytic production of some substituted 1, 5-benzodiazepines as potential orthopedic agents

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-01-29 DOI:10.1016/j.molstruc.2025.141590

Xingyu Jiang , Ning Ma , Hongwei Liu , Chunyan Zhang , Pengfei Lv , Juan Zhang

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引用次数: 0

Abstract

1, 5-Benzodiazepines are significant compounds that are commonly used in orthopedics, primarily for their anxiolytic and muscle relaxant properties. Heterogeneous catalysis offers a promising approach for conducting eco-friendly and sustainable organic transformations. Benzodiazepines are important nitrogen-containing heterocyclic compounds with numerous biological activities. The use of Fe₃O₄@CeO₂ as a catalyst for the synthesis of some substituted 1, 5-benzodiazepines is innovative and efficient. Characterization techniques including FT-IR (Fourier transform infrared), XRD (X-ray diffraction), FE-SEM (field emission scanning electron microscopy), TEM (transmission electron microscopy), EDS (energy dispersive X-ray spectroscopy), DRS (diffuse reflectance specroscopy), XPS (X-ray photoelectron spectroscopy) and VSM (vibrating magnetometry) are used to identify the catalyst physicochemical structure. Some important experimental parameters such as reaction time, mole ratio of reagents, and temperature are evaluated to assess the optimum reaction condition. The best reaction condition includes 1 mmol of aryl aldehyde, dimedone, and 1, 2-phenylenediamine in the presence of 20 mg Fe₃O₄@CeO₂ catalyst in 10 mL ethanol for 90 min. Moreover, stability and reusability studies have confirmed acceptable results for the performed catalytic reaction in multiple runs, indicating its practical applicability.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.