Intraoperative Evaluation of Pediatric Bone and Soft Tissue Lesions: Retrospective Analysis of 595 Frozen Sections With Emphasis on Discrepancy and Diagnostic Pitfalls.

Benjamin L Coiner, Hernán Correa, Joyce E Johnson, Jiancong Liang, Huiying Wang
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Abstract

Context.—: Frozen section (FS) evaluation of pediatric bone and soft tissue (BST) lesions is infrequently encountered and may pose considerable diagnostic challenges. Limited data exist about the accuracy and related diagnostic difficulties.

Objective.—: To identify and analyze discrepancy between the FS diagnosis and final diagnosis in order to increase the awareness of common diagnostic pitfalls in FS evaluation of pediatric BST lesions.

Design.—: We retrospectively reviewed 595 consecutive FSs of pediatric BST lesions from 373 patients and analyzed the accuracy and causes for interpretation errors.

Results.—: Discrepant diagnoses were found in 23 of 595 FSs (3.9%). Discrepancy rates were slightly higher in benign, soft tissue lesions and FSs requested for diagnosis/adequacy, although no statistically significant difference was observed. Pathologist misinterpretation contributed to discrepancy in 17 of 23 FSs (73.9%), which were classified into 6 patterns of error. For margin, 3 patterns were found: normal hematopoietic elements versus malignant cells in Ewing sarcoma bone marrow margin (n = 3), prominent sinonasal vasculature and stroma versus sinonasal tract angiofibroma (n = 3), and atrophic skeletal muscles versus malignant cells in rhabdomyosarcoma and Ewing sarcoma (n = 2). For diagnosis, another 3 patterns were identified: misclassification of benign bone tumors (n = 5), misclassification of benign spindle neoplasms (n = 2), and vascular malformation versus normal tissue (n = 2).

Conclusions.—: FS is a valuable tool for guiding surgical management of pediatric BST lesions, which can be challenging entities and represent significant diagnostic pitfalls. Awareness of these FS pitfalls may help in further increasing diagnostic accuracy.

术中评估儿童骨和软组织病变:回顾性分析595例冷冻切片,重点分析差异和诊断缺陷。
上下文。-:冷冻切片(FS)评估儿童骨和软组织(BST)病变是不常见的,可能会带来相当大的诊断挑战。关于其准确性和相关诊断困难的资料有限。-:识别和分析FS诊断与最终诊断之间的差异,以提高对儿童BST病变FS评估中常见诊断缺陷的认识。我们回顾性分析了373例儿童BST病变的595例连续FSs,并分析了解释错误的准确性和原因。-: 595例FSs中有23例(3.9%)诊断不一致。在良性、软组织病变和诊断/充分性要求的FSs方面,差异率略高,尽管没有观察到统计学上的显著差异。病理错误解释导致23例fs中17例(73.9%)出现差异,这些错误分为6种类型。对于边缘,发现了3种模式:尤文氏肉瘤骨髓边缘正常造血因子vs恶性细胞(n = 3),突出的鼻窦血管和间质vs鼻窦血管纤维瘤(n = 3),萎缩的骨骼肌vs恶性细胞横纹肌肉瘤和尤文氏肉瘤(n = 2)。在诊断方面,发现了另外3种模式:良性骨肿瘤分型错误(n = 5),良性梭形肿瘤分型错误(n = 2),血管畸形与正常组织(n = 2)。-: FS是指导小儿BST病变手术处理的宝贵工具,这可能是具有挑战性的实体,并代表着重大的诊断缺陷。意识到这些FS缺陷可能有助于进一步提高诊断的准确性。
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