Does clonidine stimulate copeptin in children?

IF 1 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2025-01-01 Print Date: 2025-02-25 DOI:10.1515/jpem-2024-0498

Gerhard Binder, Karin Weber, Andreas Peter, Roland Schweizer

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引用次数: 0

Abstract

Objectives: Copeptin is secreted in isomolar amounts along with AVP. Its stability makes it a perfect biomarker of AVP deficiency. In children, dynamic GH tests were shown to stimulate copeptin. Here, we retrospectively studied the effect of clonidine on copeptin release.

Methods: This is a monocentric retrospective analysis of donated residual serum samples from 42 children with suspected growth hormone deficiency (GHD) who underwent clonidine stimulation between 2020 and 2023. Copeptin was measured in baseline, 30-, 60-, 90- and 120-min samples by BRAHMS Copeptin proAVP Kryptor immunofluorescence assay.

Results: There were 20 patients with GHD and 22 without; no patient had polyuria-polydipsia syndrome. Median age was 6.7 years (quartiles; 5.6-7.8), and the median height was -2.92 SDS (-3.42 to -2.34). The median baseline level of copeptin was 5.6 pmol/L (3.4-9.6). Median copeptin mildly decreased to 4.5 pmol/L (3.0-10.0) after 30 min; this change was not significant (p=0.45). Thereafter, median values remained low at 4.6, 4.6, and 4.6 pmol/L (60, 90, and 120 min). There was no correlation between baseline copeptin levels and the diagnosis of GHD.

Conclusions: The clonidine stimulation test does not stimulate copeptin release and is not suitable for the assessment of AVP deficiency in children.

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氯尼丁会刺激儿童体内的 copeptin 吗？

目的：Copeptin随AVP以等摩尔量分泌。其稳定性使其成为AVP缺乏的完美生物标志物。在儿童中，动态生长激素试验显示刺激copeptin。在此，我们回顾性研究了可乐定对copeptin释放的影响。方法：对2020年至2023年期间接受可乐定刺激的42名疑似生长激素缺乏症（GHD）儿童捐献的剩余血清样本进行单中心回顾性分析。采用BRAHMS Copeptin proAVP Kryptor免疫荧光法测定基线、30、60、90和120分钟样品中的Copeptin。结果：有GHD的20例，无GHD的22例；无患者出现多尿-烦渴综合征。中位年龄为6.7岁(四分位数；5.6 ~ 7.8)，中位身高为-2.92 SDS（-3.42 ~ -2.34）。copeptin的中位基线水平为5.6 pmol/L（3.4-9.6）。中位copeptin在30 min后轻度下降至4.5 pmol/L (3.0-10.0)；这一变化不显著（p=0.45）。此后，中位数保持在4.6、4.6和4.6 pmol/L（60、90和120 min）。基线copeptin水平与GHD诊断无相关性。结论：可乐定刺激试验不刺激copeptin释放，不适合评估儿童AVP缺乏症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

2.70

自引率

7.10%

发文量

176

审稿时长

3-6 weeks

期刊介绍： The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.