Outcomes of COVID-19 in the Omicron-predominant wave: large-scale real-world data analysis with a comparison to influenza.

IF 8.5 Q1 RESPIRATORY SYSTEM
Koichi Miyashita, Hironao Hozumi, Kazuki Furuhashi, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Toshiyuki Ojima, Takafumi Suda
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引用次数: 0

Abstract

Purpose: Studies on COVID-19 mortality during the Omicron-predominant wave have focused primarily on the inpatient/emergency room setting, and real-world data including both inpatients and outpatients are lacking.

Methods: Patients diagnosed with COVID-19 (n = 27,440,148) or influenza (n = 8,179,641) from January 2020 to April 2023 were identified using nationwide claims data in Japan. Patients with COVID-19 in the Omicron-predominant wave were compared with their counterparts in earlier waves, and a subset of the former group (May 2022-April 2023) was compared with patients with influenza as controls.

Results: The mortality rates (average number of deaths/cases per week) of COVID-19 decreased over time, being 2.7% (169/6312), 2.1% (397/18,754), 0.7% (195/28,273), and 0.4% (1613/378,848) in the wild-type-, Alpha-, Delta-, and Omicron-predominant waves, respectively. However, the number of deaths increased substantially in the Omicron-predominant wave, especially among the elderly (e.g., in the Delta- and Omicron-predominant waves, the average numbers of deaths/cases per week were < 1/5527 (< 0.01%) and 4/105,763 (< 0.01%) respectively, in patients aged 0-19, versus 101/925 (10.9%) and 1212/20,771 (5.8%), respectively, in patients aged ≥ 80). The mortality rate was lower for patients with COVID-19 than in those with influenza among those aged ≤ 39 years but higher among those aged ≥ 40 years.

Conclusions: In the Omicron-predominant wave, the mortality rate of COVID-19 decreased, but the number of patients increased, leading to a substantial increase in the number of deaths, especially among the elderly. The mortality rate of COVID-19 was higher than that of influenza in the elderly but not in the young, highlighting the need for age-specific interventions.

在以欧米克隆病毒为主的浪潮中,COVID-19的结局:与流感比较的大规模真实世界数据分析
目的:在以omicron为主的浪潮期间,对COVID-19死亡率的研究主要集中在住院/急诊室环境中,缺乏包括住院和门诊患者在内的真实数据。方法:利用日本2020年1月至2023年4月的全国索赔数据,确定了2020年1月至2023年4月诊断为COVID-19 (n = 27,440,148)或流感(n = 8,179,641)的患者。将处于omicron优势波中的COVID-19患者与早期波中的患者进行比较,并将前一组的一部分(2022年5月至2023年4月)与流感患者作为对照进行比较。结果:随着时间的推移,COVID-19的死亡率(平均每周死亡/病例数)下降,野生型、α型、δ型和欧米克隆型主要波分别为2.7%(169/6312)、2.1%(397/ 18754)、0.7%(195/28,273)和0.4%(1613/378,848)。结论:在omicron - dominant wave中,COVID-19的死亡率下降,但患者数量增加,导致死亡人数大幅增加,尤其是老年人。COVID-19的死亡率在老年人中高于流感,但在年轻人中高于流感,这凸显了针对特定年龄的干预措施的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pneumonia
Pneumonia RESPIRATORY SYSTEM-
自引率
1.50%
发文量
7
审稿时长
11 weeks
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