A Pilot Study Using a Smartwatch to Search for Biomarkers of Heart Rate Variability in Active Ulcerative Colitis.

Q2 Medicine
Inflammatory Intestinal Diseases Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI:10.1159/000543295
Jin Imai, Masashi Ohno, Masaya Sano, Takuro Miyazaki, Hiroaki Suzuki, Atsushi Nishida, Yuto Hashida, Takashi Ueda, Haruhiko Sato, Erika Teramura, Makiko Monma, Mia Fujisawa, Ryuzo Deguchi, Nagamu Inoue, Noriaki Kishimoto, Akiyasu Baba, Masashi Matsushima, Tatehiro Kagawa, Yasuhiro Nishizaki, Akira Andoh, Hidekazu Suzuki
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引用次数: 0

Abstract

Introduction: Autonomic imbalance has been reported to correlate with clinical remission in patients with ulcerative colitis (UC). This study evaluated heart rate variability (HRV), a potential digital biomarker, in patients with active UC using a smartwatch that is easy to handle.

Methods: Patients with active UC were recruited for this prospective study. The patients' HRV was measured via the Fitbit Inspire2 linked via Bluetooth to their smartphone. HRV during nighttime sleep was obtained from continuous data. Patients were required to input the Simple Clinical Colitis Activity Index (SCCAI) score once daily by the application on their smartphones for 3 months.

Results: Nine patients with UC were included. In clinically active disease, SCCAI scores showed a weak inverse relationship with parasympathetic activity, differences of successive R-R pulse intervals (RMSSD) (r = -0.44, p < 0.0001), high frequency (HF) (r = -0.42, p < 0.0001), and total autonomic nervous activity, low frequency (LF) (r = -0.43, p < 0.0001). Receiver operating characteristic analysis indicated that the RMSSD, HF, and LF were significantly higher in patients with active UC. Meanwhile, LF showed the most correlation with severity for bowel urgency scores.

Conclusion: Longitudinal nighttime HRV recorded using a smartwatch is associated with disease activity in patients with active UC. In particular, RMSSD and HF, which are indices of the parasympathetic nervous system, have been suggested as potential digital biomarkers for UC.

一项使用智能手表搜索活动性溃疡性结肠炎心率变异性生物标志物的初步研究。
导读:据报道,自主神经失衡与溃疡性结肠炎(UC)患者的临床缓解有关。这项研究使用易于操作的智能手表评估了活动性UC患者的心率变异性(HRV),这是一种潜在的数字生物标志物。方法:前瞻性研究招募活动性UC患者。通过蓝牙连接到智能手机的Fitbit Inspire2™来测量患者的心率。从连续数据中获得夜间睡眠时的心率。患者被要求每天通过智能手机上的应用程序输入一次简单临床结肠炎活动指数(SCCAI)评分,持续3个月。结果:纳入9例UC患者。在临床活动性疾病中,SCCAI评分与副交感神经活动、连续r - r脉冲间隔(RMSSD)差异(r = -0.44, p < 0.0001)、高频(r = -0.42, p < 0.0001)、总自主神经活动、低频(r = -0.43, p < 0.0001)呈弱负相关。受试者工作特征分析显示,活动性UC患者RMSSD、HF和LF明显较高。同时,LF与肠急症评分的严重程度相关性最大。结论:使用智能手表记录的纵向夜间HRV与活动性UC患者的疾病活动有关。特别是RMSSD和HF,作为副交感神经系统的指标,被认为是UC的潜在数字生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inflammatory Intestinal Diseases
Inflammatory Intestinal Diseases Medicine-Gastroenterology
CiteScore
4.50
自引率
0.00%
发文量
6
审稿时长
20 weeks
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