Fertility in male patients with familial Mediterranean fever and paternal effect of FMF on pregnancy outcomes and complications.

IF 3.2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Kerem Parlar, Feyza Nur Azman, Sena Ladin Sıcakyüz, Melike Rızaoğlu, Enes Azman, Mebrure Burçak Yüzbaşıoğlu, Dilvin Korkmaz, Serdal Uğurlu
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Abstract

Objectives: This study investigates the impact of Familial Mediterranean Fever (FMF) and its treatment on male infertility, and the paternal effect of FMF on pregnancy outcomes or complications.

Methods: We enrolled 282 adult male FMF patients and excluded 102 for never attempting pregnancy. Demographic and clinical data, including MEFV mutation status and treatment history, were collected. Fertility status and pregnancy outcomes were assessed through interviews and medical records. Statistical analysis was performed using Fisher's exact test, with significance set at p < 0.05.

Results: Among the 180 patients who attempted pregnancy, 177 (98.3%) achieved pregnancy. Only 3 (1.7%) were infertile. A total of 452 pregnancies were conceived, with 85.0% resulting in live births. Miscarriages occurred in 11.9%, stillbirths in 0.9%, and ectopic pregnancies in 0.9%. The most common complication was preterm birth (4.2%), followed by gestational diabetes (2.1%). Eleven patients with amyloidosis achieved 39 pregnancies, with no cases of infertility.

Conclusion: FMF does not lead to decreased male fertility or adverse pregnancy outcomes. Colchicine is safe for use during conception. Male FMF patients and their partners do not need additional precautions during pregnancy attempts and follow-up.

家族性地中海热男性患者的生育能力及FMF对妊娠结局和并发症的父亲影响。
目的:探讨家族性地中海热(FMF)及其治疗对男性不育症的影响,以及FMF对妊娠结局或并发症的影响。方法:我们招募了282名成年男性FMF患者,并排除了102名从未尝试过怀孕的患者。收集人口统计学和临床资料,包括MEFV突变状态和治疗史。通过访谈和医疗记录评估生育状况和妊娠结局。采用Fisher精确检验进行统计学分析,显著性设置为p。结果:180例尝试妊娠患者中,177例(98.3%)成功妊娠。只有3例(1.7%)不育。共有452例妊娠,其中85.0%为活产。流产占11.9%,死产占0.9%,异位妊娠占0.9%。最常见的并发症是早产(4.2%),其次是妊娠期糖尿病(2.1%)。11例淀粉样变患者成功怀孕39次,无一例不孕。结论:FMF不会导致男性生育能力下降或不良妊娠结局。秋水仙碱在怀孕期间使用是安全的。男性FMF患者及其伴侣在尝试怀孕和随访期间不需要额外的预防措施。
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来源期刊
Internal and Emergency Medicine
Internal and Emergency Medicine 医学-医学:内科
CiteScore
7.20
自引率
4.30%
发文量
258
审稿时长
6-12 weeks
期刊介绍: Internal and Emergency Medicine (IEM) is an independent, international, English-language, peer-reviewed journal designed for internists and emergency physicians. IEM publishes a variety of manuscript types including Original investigations, Review articles, Letters to the Editor, Editorials and Commentaries. Occasionally IEM accepts unsolicited Reviews, Commentaries or Editorials. The journal is divided into three sections, i.e., Internal Medicine, Emergency Medicine and Clinical Evidence and Health Technology Assessment, with three separate editorial boards. In the Internal Medicine section, invited Case records and Physical examinations, devoted to underlining the role of a clinical approach in selected clinical cases, are also published. The Emergency Medicine section will include a Morbidity and Mortality Report and an Airway Forum concerning the management of difficult airway problems. As far as Critical Care is becoming an integral part of Emergency Medicine, a new sub-section will report the literature that concerns the interface not only for the care of the critical patient in the Emergency Department, but also in the Intensive Care Unit. Finally, in the Clinical Evidence and Health Technology Assessment section brief discussions of topics of evidence-based medicine (Cochrane’s corner) and Research updates are published. IEM encourages letters of rebuttal and criticism of published articles. Topics of interest include all subjects that relate to the science and practice of Internal and Emergency Medicine.
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