Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice.

IF 6.4 1区生物学 Q1 BIOLOGY

eLife Pub Date : 2025-02-05 DOI:10.7554/eLife.98714

Ning Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang

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引用次数: 0

Abstract

Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of patients with gout and hyperuricemia compared to healthy individuals. However, the link between gut microbiota and age-related gout remained underexplored. Our study found that gut microbiota plays a crucial role in determining susceptibility to age-related gout. Specifically, we observed that age-related gut microbiota regulated the activation of the NLRP3 inflammasome pathway and modulated uric acid metabolism. More scrutiny highlighted the positive impact of 'younger' microbiota on the gut microbiota structure of old or aged mice, enhancing butanoate metabolism and butyric acid content. Experimentation with butyrate supplementation indicated that butyric acid exerts a dual effect, inhibiting inflammation in acute gout and reducing serum uric acid levels. These insights emphasize the potential of gut microbiome rejuvenation in mitigating senile gout, unraveling the intricate dynamics between microbiota, aging, and gout. It potentially serves as a therapeutic target for senile gout-related conditions.

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年轻小鼠的微生物群通过调节老年小鼠的丁酸水平来抵消与年龄相关的痛风易感性。

痛风是一种常见的炎症性关节炎，由于血液中尿酸水平过高，导致关节内和周围形成尿酸盐晶体，尤其影响老年人。最近的研究提供了证据，表明痛风和高尿酸血症患者的肠道微生物群与健康个体相比存在明显差异。然而，肠道微生物群与年龄相关性痛风之间的联系仍未得到充分探讨。我们的研究发现，肠道微生物群在决定年龄相关性痛风的易感性方面起着至关重要的作用。具体来说，我们观察到与年龄相关的肠道微生物群调节NLRP3炎性体途径的激活并调节尿酸代谢。更多的研究强调了“年轻”微生物群对老年小鼠肠道微生物群结构的积极影响，增强了丁酸代谢和丁酸含量。补充丁酸的实验表明，丁酸具有抑制急性痛风炎症和降低血清尿酸水平的双重作用。这些见解强调了肠道微生物群再生在缓解老年性痛风方面的潜力，揭示了微生物群、衰老和痛风之间复杂的动态关系。它有可能作为老年性痛风相关疾病的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

eLife BIOLOGY-

CiteScore

12.90

自引率

3.90%

发文量

3122

审稿时长

17 weeks

期刊介绍： eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.