Solubility determination and correlation, solvent effect and thermodynamics of itraconazole in sixteen mono solvents and ternary mixtures of N-methyl-2-pyrrolidone, diethylene glycol monoethyl ether, and ethanol

IF 2.2 3区工程技术 Q3 CHEMISTRY, PHYSICAL

Journal of Chemical Thermodynamics Pub Date : 2025-01-12 DOI:10.1016/j.jct.2025.107455

Eun-Sol Ha , Heejun Park , Seon-Kwang Lee , Hui-Taek Kang , Ji-Su Jeong , In-hwan Baek , Min-Soo Kim

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引用次数: 0

Abstract

In this study, the experimental mole fraction solubility of itraconazole in 16 mono solvents (acetone, acetonitrile, 1-butanol, chloroform, DEGME, dichloromethane, DMA, DMF, DMSO, ethanol, methanol, NMP. 1-propanol, 2-propanol, tetrahydrofuran, and water) and ternary solvent system (NMP + DEGME + ethanol) was determined using the well-known shake-flask technique. The rank order of solubility of itraconazole in sixteen mono solvents at 298.15 K is as follows: chloroform (5.04 × 10⁻²) > dichloromethane (3.27 × 10⁻²) > NMP (2.20 × 10⁻²) > DMA (1.18 × 10⁻²) > DMF (1.07 × 10⁻²) > tetrahydrofuran (2.12 × 10⁻³) > DMSO (1.75 × 10⁻³) > DEGME (7.30 × 10⁻⁴) > acetone (6.37 × 10⁻⁴) > acetonitrile (7.95 × 10⁻⁵) > methanol (3.79 × 10⁻⁵) > 1-butanol (2.30 × 10⁻⁵) > 2- propanol (2.14 × 10⁻⁵) > 1-propanol (2.05 × 10⁻⁵) > ethanol (1.91 × 10⁻⁵) > water (2.43 × 10⁻⁷). According to the regression results of the KAT-LSER model, the solubility of itraconazole was principally affected by dipolarity/polarizability and solvent–solvent interaction. The mole fraction solubility of itraconazole increased with the increasing temperature and mass fraction of NMP in the ternary mixtures (NMP + DEGME + ethanol). In addition, the solubility parameters were applied to comprehensively understand and describe the solubility of itraconazole in a ternary solvent system. Four thermodynamic models, including van’t Hoff model, modified Apelblat model, Jouyban–Acree model, and Jouyban–Acree–van’t Hoff model, were used to fit the solubility data of itraconazole. The thermodynamic properties of itraconazole during the dissolution processes were estimated using the Gibbs equation and modified van’t Hoff analysis. The solid–liquid equilibrium solubility in sixteen different mono solvents and ternary solvent systems, solvent effect on the solubility, four correlation models, and thermodynamic properties could be helpful for pre-formulation study, extraction, purification, crystallization, and development of liquid formulation, including topical solution.

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来源期刊

Journal of Chemical Thermodynamics 工程技术-热力学

CiteScore

5.60

自引率

15.40%

发文量

199

审稿时长

79 days

期刊介绍： The Journal of Chemical Thermodynamics exists primarily for dissemination of significant new knowledge in experimental equilibrium thermodynamics and transport properties of chemical systems. The defining attributes of The Journal are the quality and relevance of the papers published. The Journal publishes work relating to gases, liquids, solids, polymers, mixtures, solutions and interfaces. Studies on systems with variability, such as biological or bio-based materials, gas hydrates, among others, will also be considered provided these are well characterized and reproducible where possible. Experimental methods should be described in sufficient detail to allow critical assessment of the accuracy claimed. Authors are encouraged to provide physical or chemical interpretations of the results. Articles can contain modelling sections providing representations of data or molecular insights into the properties or transformations studied. Theoretical papers on chemical thermodynamics using molecular theory or modelling are also considered. The Journal welcomes review articles in the field of chemical thermodynamics but prospective authors should first consult one of the Editors concerning the suitability of the proposed review. Contributions of a routine nature or reporting on uncharacterised materials are not accepted.