Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock

Journal of molecular and cellular cardiology plus Pub Date : 2025-01-17 DOI:10.1016/j.jmccpl.2025.100284

Tuomas Mäntylä , Chunguang Wang , Mikko Hänninen , Katariina Immonen , Toni Jäntti , Johan Lassus , Ilkka Tikkanen , Kari Pulkki , Yvan Devaux , Veli-Pekka Harjola , Päivi Lakkisto , CardShock Study Investigators

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Abstract

Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adverse outcomes. This study aimed to investigate the prognostic potential of microRNAs (miRNAs) in assessment of the outcome of cardiogenic shock.

Circulating miRNA levels were measured by quantitative PCR in plasma samples collected at baseline from 165 patients of the multicenter, prospective, observational CardShock study and compared between in-hospital and 90-day survivors and non-survivors. Of the 10 studied miRNAs, median levels of miR-20b-5p at baseline were significantly higher in in-hospital and 90-day survivors compared to non-survivors [median 0.014 arbitrary units (AU) (interquartile range (IQR) 0.003–0.024) vs. 0.008 AU (IQR 0.001–0.015), p = 0.013] and [0.015 AU (IQR 0.003–0.025) vs. 0.010 AU (IQR 0.001–0.015), p = 0.012], respectively. In Cox regression analysis, miR-20b-5p levels in the highest quartile were significantly associated with 90-day survival (adjusted hazard ratio 2.47 (95 % confidence interval 1.16–5.28), p = 0.019) when adjusted for CardShock Risk Score variables (age, confusion at presentation, previous myocardial infarction or coronary artery bypass grafting, acute coronary syndrome (ACS) etiology, left ventricular ejection fraction, lactate, and estimated glomerular filtration rate). A similar association of highest quartile miR-20b-5p levels with 90-day survival was also confirmed in ACS patient subcohort (79 % of CS patients).

The results of this study indicate that circulating levels of miR-20b-5p at baseline could help in assessing in-hospital and 90-day survival in CS patients.

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