Leveraging Action Unit Derivatives for Early-Stage Parkinson's Disease Detection

IF 5.6 4区医学 Q1 ENGINEERING, BIOMEDICAL

Irbm Pub Date : 2025-02-01 DOI:10.1016/j.irbm.2024.100874

Anas Filali Razzouki , Laetitia Jeancolas , Graziella Mangone , Sara Sambin , Alizé Chalançon , Manon Gomes , Stéphane Lehéricy , Jean-Christophe Corvol , Marie Vidailhet , Isabelle Arnulf , Dijana Petrovska-Delacrétaz , Mounim A. El-Yacoubi

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引用次数: 0

Abstract

Objective

Hypomimia is a symptom of Parkinson's disease (PD), involving a decrease in facial movements and a loss of emotional expressions on the face. The objective of this study is to identify hypomimia in individuals in the early stage of PD by analyzing facial action units (AUs).

Methods

Our study included video recordings from 109 PD subjects and 45 healthy control (HC) subjects with an average of two videos per person (294 videos in total). The participants were requested to perform rapid syllable repetitions. For the purpose of discriminating between normal facial muscle movements and those specific to PD subjects experiencing hypomimia, we calculate the derivatives of the AUs. We derive global features based on the AUs intensities and their derivatives, and utilize XGBoost and Random Forest to perform the classification between PD and HC.

Results

We achieve subject-level classification scores of up to 73.7% for balanced accuracy (BA) and an area under the curve (AUC) of 81.39% using XGBoost, and a BA of 79.1% and an AUC of 83.7% with Random Forest. These findings show potential in identifying hypomimia during the early phases of PD. Moreover, this research could facilitate the continuous monitoring of hypomimia beyond hospital settings, enabled by telemedicine.

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来源期刊

Irbm ENGINEERING, BIOMEDICAL-

CiteScore

10.30

自引率

4.20%

发文量

审稿时长

57 days

期刊介绍： IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux). As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in: -Physiological and Biological Signal processing (EEG, MEG, ECG…)- Medical Image processing- Biomechanics- Biomaterials- Medical Physics- Biophysics- Physiological and Biological Sensors- Information technologies in healthcare- Disability research- Computational physiology- …