Chemical preparation, thermal behavior, magnetic properties and biological activities of a new manganese chloride templated by piperazine (C4H12N2)[MnCl4(H2O)2]

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2024-12-18 DOI:10.1016/j.ica.2024.122509

Ines Kadri , Amal Ben Hassena , Fatma Aouaini , Beriham Basha , Hajir Wahbi , Fatma Saadi , Wesam Abd El-Fattah , Antonio Sánchez-Coronilla , Walid Rekik , Houcine Naïli

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Abstract

In this work, we study a new manganese chloride templated by piperazine with the general formula (C₄H₁₂N₂)[MCl₄(H₂O)₂] that exhibits interesting properties and biological activities. The crystalline structure of (C₄H₁₂N₂)[MnCl₄(H₂O)₂] consists of anionic and cationic entities bound together by hydrogen bonds. The anionic part of this complex is formed by the diaquatetrachloromanganate(II) octahedra [MnCl₄(H₂O)₂]²⁻, while the cationic part is composed of an organic component (protonated piperazine (C₄H₁₂N₂)²⁺). The thermal behavior of (C₄H₁₂N₂)[MnCl₄(H₂O)₂] was studied by TGA (thermogravimetric analysis) between 50 and 860 °C under flowing air and by DSC (differential scanning calorimetry) in the temperature range of 25–400 °C, with a heating rate of 10 °C min⁻¹. The title compound decomposes in three steps leading to the formation of manganese oxides, Mn₂O₃ and Mn₃O₄. The magnetic measurements indicate that (C₄H₁₂N₂)[MnCl₄(H₂O)₂] is predominantly paramagnetic with weak antiferromagnetic interactions between the Mn²⁺ centers, which presents five single electrons and adopts the high spin state. Regarding its biological activities, (C₄H₁₂N₂)[MnCl₄(H₂O)₂] exhibited a significant antioxidant capacity as measured by the DPPH assay. Additionally, in response to the urgent need for new antimicrobial drugs due to growing antibiotic resistance, the title compound was further evaluated for its antibacterial activity through the well diffusion test followed by the microdilution method. Bacterial growth inhibition and MBC/MIC determinations demonstrated the efficacy of (C₄H₁₂N₂)[MnCl₄(H₂O)₂] in killing various pathogenic bacteria. These findings highlight the significant biological activities of the compound, particularly its potential capacity to combat resistant bacteria.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.