DNA interaction and cytotoxicity of a new asymmetric dimer cobalt(II) complex [Co(phen)2(Cl2)]3(H2O).[Co(phen)2(Cl)(H2O)](Cl)

Chemistry of Inorganic Materials Pub Date : 2024-12-01 DOI:10.1016/j.cinorg.2024.100071

P. Gurumoorthy , S. Ulaganathan , S. Baskaran

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Abstract

The new, unusual and asymmetric cobalt(II) complex, [Co(phen)₂(Cl₂)]3(H₂O).[Co(phen)₂(Cl)(H₂O)](Cl) (phen = 1,10-phenanthroline), has been synthesized and characterized structurally by regular spectral and single crystal XRD analysis. An asymmetric complex crystallized in a monoclinic system with space group P2₁/c, a = 14.093(5) Å, b = 24.089(5) Å, c = 14.241(5) Å, α = 90.000(5)^°, β = 98.010(5)^°, and γ = 90.000(5)^°. DNA binding interactions of complex with calf thymus DNA (CT-DNA) has investigated by UV–Vis absorption, ethidium bromide displacement assay, viscometric and cyclic voltammetric titrations, and the results infer an intercalation mode of binding. Complex cleaves effectively plasmid pBR322 DNA, and exhibits remarkable cytotoxic activity against human colon cancer cell line (HCT15).

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Chemistry of Inorganic Materials

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