Antibody Drug Conjugates (ADCs): Shaping the Future of Precision Oncology.

IF 2.6 4区 医学 Q3 CHEMISTRY, MEDICINAL
Irene Sevilla-Carrillo, Eloína García-Tercero, Carlos Alonso-Moreno, Carmen Moya-Lopez
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引用次数: 0

Abstract

Antibody-drug conjugates (ADCs) are a groundbreaking advancement in targeted cancer therapy, combining the precision of monoclonal antibodies with the potency of cytotoxic drugs. This review first outlines the components of ADCs and their mechanisms of action before providing a comprehensive overview of the current state of ADC technology. It covers both FDA-approved ADCs and those in various stages of clinical development, as well as future research directions. The review also explores recent innovations, such as bispecific antibodies and pro-body-drug conjugates, which offer promising new strategies for improving efficacy and minimizing off-target effects. The review emphasizes the need for ongoing research to optimize ADC design and develop novel approaches to enhance their therapeutic potential.

抗体药物偶联物(adc):塑造精准肿瘤的未来。
抗体-药物偶联物(adc)结合了单克隆抗体的精确性和细胞毒性药物的效力,是靶向癌症治疗领域的一项突破性进展。本文首先概述了ADC的组成部分及其作用机制,然后对ADC技术的现状进行了全面概述。它涵盖了fda批准的adc和处于临床开发各个阶段的adc,以及未来的研究方向。本综述还探讨了最近的创新,如双特异性抗体和前体药物偶联物,它们为提高疗效和减少脱靶效应提供了有希望的新策略。该综述强调需要进行持续研究以优化ADC设计和开发新方法以增强其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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