Green Construction of Novel 3-(Benzo[d][1,3]dioxol-5-yl)-1,8-naphthyridin-2-yl)amino)quinazoline-2,4(1H,3H)-dione and Phenyl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine and Their Antimicrobial Activity

Abstract

A straightforward and an efficient green synthetic method has been outlined for the construction of 3-(benzo[d][1, 3] dioxol-5-yl)-1,8-naphthyridine derivatives in the presence of glacial acetic acid and Cu(OAc)₂ catalyst accomplished excellent yields in short reaction time. The reaction proceeds efficiently by using a greener way under microwave conditions to elevate the quantity of pure products. The purity of all the synthesized compounds was confirmed by IR, ¹H and ¹³CNMR, LC–MS data and also from the elemental analyses studies. The synthesized compounds 7d and 7f performed strongest antibacterial activity against pathogenic cell lines Bacillus subtilis (17.5, 20.5 mm), Escherichia coli (28.5, 30 mm), and antifungal cell lines Candida albicans (18, 22.5 mm), and Aspergillus Niger (28.5, 40.5 mm) which are compared with clinical drugs Penicillin, Grieseofulvin. We scrutinized the remaining molecules and found that their activity ranged from modest to exceptional.