Potassium tantalum niobate: Structural insights and biocompatibility for biomedical applications

IF 3.5 3区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Journal of the American Ceramic Society Pub Date : 2024-11-25 DOI:10.1111/jace.20261

M. Durga Ganesh, Subingya Pandey, Mukesh Kumar Manickasamy, Ajaikumar B. Kunnumakkara, Pamu Dobbidi

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引用次数: 0

Abstract

This study explores the biomedical applications of electrically active potassium tantalum niobate (KTN) ceramics (KTa_1 −_xNb_xO₃; where x = 0.0, 0.1, 0.3, 0.5, and 0.7), focusing on their dielectric and biological properties for bioelectrets and electroactive scaffolds. Varying Nb concentrations induced a structural shift from cubic to orthorhombic phases, with increased Nb inhibiting grain growth and maintaining stoichiometry. Dielectric analysis across temperatures and frequencies revealed two phase transitions (orthorhombic to tetragonal at 433–453 K and tetragonal to cubic at 653–703 K). Nyquist plots indicated reduced bulk resistance with increasing temperature. The AC conductivity (10⁻⁴ S/cm) suggests potential enhancement in bone regeneration scaffolds. Bioactivity assessments showed negative surface charges promoting dense apatite layer formation, while cytocompatibility studies demonstrated robust cell proliferation (>100% by Day 3 for PSVK-1 and Wi-38 cell lines). This comprehensive investigation underscores KTN ceramics' promise for biomedical applications in enhancing electrical properties and fostering favorable biological interactions.

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来源期刊

Journal of the American Ceramic Society 工程技术-材料科学：硅酸盐

CiteScore

7.50

自引率

7.70%

发文量

590

审稿时长

2.1 months

期刊介绍： The Journal of the American Ceramic Society contains records of original research that provide insight into or describe the science of ceramic and glass materials and composites based on ceramics and glasses. These papers include reports on discovery, characterization, and analysis of new inorganic, non-metallic materials; synthesis methods; phase relationships; processing approaches; microstructure-property relationships; and functionalities. Of great interest are works that support understanding founded on fundamental principles using experimental, theoretical, or computational methods or combinations of those approaches. All the published papers must be of enduring value and relevant to the science of ceramics and glasses or composites based on those materials. Papers on fundamental ceramic and glass science are welcome including those in the following areas: Enabling materials for grand challenges[...] Materials design, selection, synthesis and processing methods[...] Characterization of compositions, structures, defects, and properties along with new methods [...] Mechanisms, Theory, Modeling, and Simulation[...] JACerS accepts submissions of full-length Articles reporting original research, in-depth Feature Articles, Reviews of the state-of-the-art with compelling analysis, and Rapid Communications which are short papers with sufficient novelty or impact to justify swift publication.