Alkylcyanation of Unactivated Alkenes with Protic C(sp3)−H Feedstocks via Radical-Initiated Intramolecular Cyano Group Migration Enabled by Photoredox/Brønsted Base Dual Catalysis

IF 3 4区化学 Q3 CHEMISTRY, PHYSICAL

ChemPhotoChem Pub Date : 2024-10-18 DOI:10.1002/cptc.202400282

Yang Hong, Hong-Ping Deng

引用次数: 0

Abstract

Cyanofunctionalization of alkenes via radical-initiated cyano migration was a straightforward pathway to access alkyl nitriles. Herein, By the synergistic merger of photoredox catalysis and Brønsted base catalysis, a mild protocol of alkylcyanation of unactivated alkenes with protic C(sp³)−H feedstocks via intramolecular 1,4-cyano group migration was reported. This method was enabled in an atom-, and step-economy manner, delivering a series of γ-cyanoester derivatives in moderate to excellent yields.

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来源期刊

ChemPhotoChem Chemistry-Physical and Theoretical Chemistry

CiteScore

5.80

自引率

5.40%

发文量

165

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