Fabrication of an antifouling and acid/alkali-resistant sulfonated polyethersulfone (S-PES)/polysulfate (PSE) composite ultrafiltration membrane and its application in the desalination of ulinastatin

IF 2.8 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of chemical technology and biotechnology Pub Date : 2024-11-14 DOI:10.1002/jctb.7782

Wei Wang, Peipei Li, Jiaqi Wang, Baiyu Xu

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引用次数: 0

Abstract

BACKGROUND

An antifouling and acid/alkali-resistant sulfonated polyethersulfone (S-PES)/polysulfate (PSE) composite ultrafiltration (UF) membrane prepared via a nonsolvent-induced phase separation (NIPS) method was used for the purification of ulinastatin (UTI) as an examplar protein-based drug.

RESULT

The effect of the content of S-PES on the structure and UF performance of the S-PES/PSE composite UF membrane was investigated. The acid/alkaline resistance of the S-PES/PSE membranes was evaluated in the pH range 5–10 suitable for a UTI solution. UF desalination experiments were carried out on UTI elution collection solution, and the antifouling performance and long-term stability of S-PES/PSE composite UF membrane were evaluated. The results indicate that, for the optimal content of 4% S-PES, pure water flux increased from 120 to 726 L m⁻² h⁻¹, WCA decreased from 79.3° to 51.0°, and the rejection of UTI was 95.90% ± 1.1% compared to PSE. Compared with PES and PSF membranes, the flux recovery rate of the S-PES/PSE composite UF membrane was 80.63% (an increase of 32.48%), and the UTI adsorption was only 75.00 μg cm⁻² (a decrease of 88.00%) after simulated antifouling experiments.

CONCLUSION

The S-PES/PSE composite UF membrane has excellent long-term stability, suggesting significant potential for application in the purification of protein-based drugs and in large-scale UTI purification. © 2024 Society of Chemical Industry (SCI).

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.