The Relationship Between Long Covid Symptoms and Vaccination Status in COVID-19 Survivors

IF 2.1 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

Journal of evaluation in clinical practice Pub Date : 2025-02-03 DOI:10.1111/jep.70004

Furkan Öztürk, Canan Emiroğlu, Cenk Aypak

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引用次数: 0

Abstract

Background

The positive effects of vaccination status on the course of Long COVID symptoms have not been fully elucidated. Our aim is to determine the most common Long COVID symptoms in patients monitored in the COVID-19 follow-up clinic and to examine whether there is a difference between the recovery rates of those who are vaccinated and those who are not vaccinated.

Method

Between December 1, 2020 and April 30, 2022, prospectively collected data of 916 patients who were admitted to the COVID-19 follow-up outpatient clinic of a tertiary hospital for the first time were evaluated as a retrospective cohort in this study. The frequencies of the ten most common symptoms in the first and last examinations of 478 patients with Long COVID symptoms were determined, and their recovery was compared. Patients were divided into two groups according to their vaccination status. The values showing the recovery rates obtained for these two groups were compared between themselves again.

Results

The average age of the patients in the study group was 54.43 ± 11.71 years, and 255 (53.3%) were male. The median follow-up period was 10 months. 84.7% of patients had received at least one dose of vaccine. Statistically significant results were found for improvement in all ten symptoms in vaccinated patients compared to the never-vaccinated group. There was no statistically significant difference between the CoronaVac, BNT162b2, and heterologous (CoronaVac+ BNT162b2) vaccine groups. Factors affecting recovery for the three most common symptoms (dyspnea, fatigue, forgetfulness) were examined with univariate logistic regression analysis, and only vaccination or non-vaccination was found to be a significant risk factor.

Conclusion

This study showed that receiving vaccination may be effective in improving Long COVID symptoms. Although there were no statistically significant differences between the inactive vaccine CoronaVac, the mRNA vaccine BNT162b2, and the heterologous (CoronaVac+ BNT162b2) vaccine in terms of reducing Long COVID symptoms, higher recovery rates were detected in those who received the mRNA vaccine BNT162b2.

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Covid -19幸存者长时间Covid -19症状与疫苗接种状况的关系

背景疫苗接种状况对长期COVID症状过程的积极影响尚未完全阐明。我们的目的是确定在COVID-19随访诊所监测的患者中最常见的长COVID症状，并检查接种疫苗者和未接种疫苗者的康复率是否存在差异。方法前瞻性收集某三级医院2020年12月1日至2022年4月30日首次就诊的新型冠状病毒肺炎随访门诊916例患者的资料，作为回顾性队列进行评价。对478例长冠状病毒症状患者进行初、末次检查，确定10种最常见症状的出现频率，并比较其康复情况。根据接种情况将患者分为两组。再次比较两组所获得的恢复率值。结果研究组患者平均年龄54.43±11.71岁，男性255例（53.3%）。中位随访期为10个月。84.7%的患者至少接种了一剂疫苗。与未接种疫苗的患者相比，接种疫苗的患者在所有十种症状方面均有显著改善。CoronaVac、BNT162b2和异源（CoronaVac+ BNT162b2）疫苗组之间的差异无统计学意义。影响三种最常见症状（呼吸困难、疲劳、健忘）恢复的因素采用单变量logistic回归分析，发现只有接种疫苗或未接种疫苗是显著的危险因素。结论接种疫苗可有效改善长冠肺炎症状。虽然灭活疫苗CoronaVac、mRNA疫苗BNT162b2和异源疫苗（CoronaVac+ BNT162b2）在减轻长冠状病毒症状方面没有统计学差异，但接种mRNA疫苗BNT162b2的患者恢复率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of evaluation in clinical practice 医学-卫生保健

CiteScore

4.80

自引率

4.20%

发文量

143

审稿时长

3-8 weeks

期刊介绍： The Journal of Evaluation in Clinical Practice aims to promote the evaluation and development of clinical practice across medicine, nursing and the allied health professions. All aspects of health services research and public health policy analysis and debate are of interest to the Journal whether studied from a population-based or individual patient-centred perspective. Of particular interest to the Journal are submissions on all aspects of clinical effectiveness and efficiency including evidence-based medicine, clinical practice guidelines, clinical decision making, clinical services organisation, implementation and delivery, health economic evaluation, health process and outcome measurement and new or improved methods (conceptual and statistical) for systematic inquiry into clinical practice. Papers may take a classical quantitative or qualitative approach to investigation (or may utilise both techniques) or may take the form of learned essays, structured/systematic reviews and critiques.