{"title":"Supercritical Fluid Extraction of Avermectin from Streptomyces avermitilis Using Carbon Dioxide","authors":"A. D. Ivakhnov, T. E. Skrebets","doi":"10.1134/S1990793124701033","DOIUrl":null,"url":null,"abstract":"<p>The process of supercritical fluid extraction (SCFE) of avermectin from the bacterial biomass of <i>Streptomyces avermitilis</i> with carbon dioxide is optimized by the method of a full factorial experiment using a second-order rotatable uniform plan. In the planning, the main levels chosen are a pressure of 25 MPa, a temperature of 60°C, and an extraction duration of 100 min. The analysis of the regression equation makes it possible to establish the optimal process parameters: 30 MPa, 85°C, and 133 min. In the control experiment, an extract is obtained with a yield of 13%, containing 41% avermectin. The yield of avermectin of an absolutely dry (a.d.) biomass is 5.36%, which exceeds the extraction yields obtained using organic solvents.</p>","PeriodicalId":768,"journal":{"name":"Russian Journal of Physical Chemistry B","volume":"18 7","pages":"1737 - 1744"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry B","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1990793124701033","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The process of supercritical fluid extraction (SCFE) of avermectin from the bacterial biomass of Streptomyces avermitilis with carbon dioxide is optimized by the method of a full factorial experiment using a second-order rotatable uniform plan. In the planning, the main levels chosen are a pressure of 25 MPa, a temperature of 60°C, and an extraction duration of 100 min. The analysis of the regression equation makes it possible to establish the optimal process parameters: 30 MPa, 85°C, and 133 min. In the control experiment, an extract is obtained with a yield of 13%, containing 41% avermectin. The yield of avermectin of an absolutely dry (a.d.) biomass is 5.36%, which exceeds the extraction yields obtained using organic solvents.
期刊介绍：
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
