Polymeric Film Loaded with Plinia cauliflora Peels Extract has a Differential Curative Effect on Injuries

Abstract

Purpose

Bioprospect a polymeric film containing P. cauliflora extract (PCE) for the differential treatment of skin injuries.

Methods

Films containing 1%, 3% and 5% of PCE were prepared and subjected to physicochemical characterization, including thickness measurement, mechanical and barrier property analysis, colorimetric evaluation, FTIR, release profiles and antimicrobial properties. Additionally, in vivo wound healing efficacy was evaluated over 21 days.

Results

The films displayed uniform thickness and high malleability. Incorporating PCE improved water solubility, reduced water vapor permeability rate and moisture absorption capacity. The bioactive release was sustained for over 24 h, ensuring an extended therapeutic window. These properties make them ideal for topical applications by providing a structured matrix for controlled bioactive release upon wound contact. This design maintains a moist environment, prevents adherence to the wound, and minimizes common issues associated with traditional treatments, such as tissue trauma during dressing changes. Antimicrobial analysis confirmed the inhibitory activity against Staphylococcus aureus in films loaded with 3% and 5% PCE. In vivo studies demonstrated accelerated wound healing with a film loaded with 5% PCE.

Conclusion

The films loaded with 5% PCE demonstrated optimal therapeutic efficacy by promoting wound healing and providing sustained antimicrobial activity, thereby serving as a viable alternative to conventional films. These films offer a structured bioactive matrix with controlled release. Unlike conventional treatments such as ointments, they offer a promising and innovative approach for skin injury treatment.