The pharmacokinetics of sulpiride and its effect on sexual behaviours and LH concentrations in anestrous does (Capra hircus)

IF 1.6 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Small Ruminant Research Pub Date : 2025-01-15 DOI:10.1016/j.smallrumres.2025.107442

Murat Yuksel , Orhan Corum , Mehmet Bugra Kivrak , Duygu Durna Corum , Erdinc Turk , Abdurrahman Takci , Sara Busra Yardımci , Mehmet Akif Demirel , Kamil Uney

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Abstract

The aim of this study was to investigate the pharmacokinetics of sulpiride and its effect on sexual behaviours and LH concentrations in anestrous does (Capra hircus). This study was carried out in two stages: pharmacokinetics (stage I) and effect on LH pulsatility, concentration, and estrus display (stage II). In the stage I, sulpiride was administered via intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral routes to does at a dose of 0.6 mg/kg. In the stage II, sulpiride was administered intramuscularly at a dose of 0.6 mg/kg every 12 hours for 10 days. Plasma concentrations of sulpiride were measured using HPLC and pharmacokinetic parameters were calculated by non-compartmental analysis. LH concentrations were quantified using ELISA. The terminal elimination half-life, apparent volume of distribution, and total body clearance of sulpiride following IV administration were 1.76 h, 0.38 L/kg, and 0.15 L/h/kg, respectively. The peak plasma concentration of IM and SC administration was 1.39 and 0.83 μg/mL at 0.53 and 0.78 h, respectively. The bioavailability of sulpiride was 103.30 % for the IM route and 72.21 % for the SC route. Sulpiride showed erratic and low absorption after oral administration. While LH concentrations decreased significantly after sulpiride administration, the LH plus frequency increased significantly. In conclusion, sulpiride with distinctive effect on LH pulse frequency has the potential to be used in protocols for hastening cyclicity. However, more studies are needed on the use of sulpiride in estrus induction protocols.

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舒必利药代动力学及其对性行为和黄体生成素浓度的影响（Capra hircus）

本研究的目的是研究舒必利的药代动力学及其对性行为和黄体生成素浓度的影响。本研究分两个阶段进行：药代动力学（I期）和对LH脉搏、浓度和发情表现的影响（II期）。在I期，舒匹利通过静脉注射（IV）、肌肉注射（IM）、皮下注射（SC）和口服给药，剂量为0.6 mg/kg。在II期，舒必利以每12 小时0.6 mg/kg的剂量肌肉注射，持续10天。采用高效液相色谱法测定舒必利血药浓度，采用非区室分析计算药动学参数。采用酶联免疫吸附测定LH浓度。静脉给药后舒匹利的终末消除半衰期为1.76 h，表观分布容积为0.38 L/kg，全身清除率为0.15 L/h/kg。在0.53和0.78 h时，IM和SC的血药浓度分别为1.39和0.83 μg/mL。IM和SC途径的生物利用度分别为103.30 %和72.21 %。口服舒必利吸收不稳定，吸收低。服用舒必利后LH浓度明显降低，但LH +频率明显增加。综上所述，对LH脉冲频率有显著影响的舒必利有可能用于加速循环的方案。然而，关于舒必利在诱导发情方案中的应用还需要更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small Ruminant Research 农林科学-奶制品与动物科学

CiteScore

3.10

自引率

11.10%

发文量

210

审稿时长

12.5 weeks

期刊介绍： Small Ruminant Research publishes original, basic and applied research articles, technical notes, and review articles on research relating to goats, sheep, deer, the New World camelids llama, alpaca, vicuna and guanaco, and the Old World camels. Topics covered include nutrition, physiology, anatomy, genetics, microbiology, ethology, product technology, socio-economics, management, sustainability and environment, veterinary medicine and husbandry engineering.