The size of local recurrence influences outcomes in chondrosarcoma: Significant impact observed in grade 2 tumours

Q2 Medicine

Journal of Clinical Orthopaedics and Trauma Pub Date : 2025-01-01 DOI:10.1016/j.jcot.2024.102866

G. Kask, M.K. Laitinen, M.C. Parry, V.J. Kurisunkal, G.V. Morris, J.D. Stevenson, L.M. Jeys

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Abstract

Background

Chondrosarcoma is the second most common bone malignancy. Chondrosarcoma is considered a surgical disease, and the role of surgical margin is important since local recurrence is known to decrease survival. The aim of this study was to investigate the timing of local recurrence and the size of local recurrence in post local recurrence survival in chondrosarcoma.

Methods

We reviewed data from one international tertiary sarcoma hospital. Between 1990 and 2022, 911 patients with chondrosarcoma of the pelvis and extremities were identified and 161 (18 %) had a local recurrence. Competing risk analysis was used to identify the timing and size of local recurrence in post local recurrence survival in different grades.

Results

Increasing size of local recurrence was a statistically significant negative factor in grade 2 chondrosarcoma patients. The timing of local recurrence was not significant for post local recurrence survival. Only 7 % of the local recurrences in high grade tumours were detected after five years after index surgery.

Conclusion

In this study we have shown that the size of local recurrence emerges as a significant factor in grade 2 tumours. Timing of local recurrence does not significantly predict the post local recurrence survival. Moreover, only 7 % of local recurrences are detected after five years in high grade tumours. Therefore, we recommend that active surveillance efforts be particularly focused on grade 2 chondrosarcomas during the initial five years after index surgery.

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来源期刊

Journal of Clinical Orthopaedics and Trauma Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

0.00%

发文量

181

审稿时长

92 days

期刊介绍： Journal of Clinical Orthopaedics and Trauma (JCOT) aims to provide its readers with the latest clinical and basic research, and informed opinions that shape today''s orthopedic practice, thereby providing an opportunity to practice evidence-based medicine. With contributions from leading clinicians and researchers around the world, we aim to be the premier journal providing an international perspective advancing knowledge of the musculoskeletal system. JCOT publishes content of value to both general orthopedic practitioners and specialists on all aspects of musculoskeletal research, diagnoses, and treatment. We accept following types of articles: • Original articles focusing on current clinical issues. • Review articles with learning value for professionals as well as students. • Research articles providing the latest in basic biological or engineering research on musculoskeletal diseases. • Regular columns by experts discussing issues affecting the field of orthopedics. • "Symposia" devoted to a single topic offering the general reader an overview of a field, but providing the specialist current in-depth information. • Video of any orthopedic surgery which is innovative and adds to present concepts. • Articles emphasizing or demonstrating a new clinical sign in the art of patient examination is also considered for publication. Contributions from anywhere in the world are welcome and considered on their merits.