P-61 CLINICAL APPLICATION OF NAFLD FIBROSIS SCORE AND HEPAMET FIBROSIS SCORE IN CORONARY ARTERY DISEASE AND MASLD: A CROSS-SECTIONAL STUDY IN WESTERN MEXICAN POPULATION

Abstract

Conflict of interest

No

Introduction and Objectives

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Reliable knowledge of the prevalence of occult CAD, particularly anatomically confirmed CAD is limited and cardiovascular risk (CVR) models only predict the risk of an acute coronary event within a set period. It has been described that a FIB-4 score is associated with a higher CVR. Objective: to determine the utility of noninvasive markers of liver fibrosis in CAD.

Patients / Materials and Methods

A cross-sectional study in western Mexican population was conducted in two tertiary centers in central and western Mexico from March 2019 to April 2023. Patients with MASLD according to the latest recommendations (hepatic steatosis demonstrated by imaging study and at least one cardiometabolic criteria) who required percutaneous coronary angiography were included, demographic data and coronary angiographic were recorded. Noninvasive fibrosis indexes were calculated. Continuous variables were subjected to a distribution analysis and equality of variances to subsequently perform a mean comparison analysis with U-Mann-Whitney test between patients with monovascular, bivascular and trivascular involvement. A correlation analysis was also performed between the invasive markers and the Syntax index.

Results and Discussion

A total of 168 patients were included with a mean age of 66 ± 12 years with a predominance of male sex with 75.6% (n= 127). Angiographic findings included 37.5%, monovascular, 32.7%, bivascular and 29.8% trivascular involvement. Comparison of means of noninvasive markers of fibrosis demonstrated a significant difference in HFS between patients with monovascular (0.17 ± 0.18), bivascular (0.27 ± 0.18) and trivascular (0.30 ± 0.25) coronary artery disease, p≤ 0.001. A correlation was also demonstrated between non-invasive markers and Syntax score: FIB-4 (r=: 820, p≤0.001), APRI (r=: 766, p≤0.001), HFS (r= 869, p≤0.001), (r= 820, p≤0.001), NFS (r= 807 p≤0.001).

Conclusions

The score of noninvasive tools to assess liver fibrosis correlates positively with the complexity of CAD and could be considered as noninvasive tools to be used in the CVR assessment in MASLD patients.