Collision tumor of the pancreas: Extraskeletal Ewing-like sarcoma and solid pseudopapillary tumor

Abstract

A collision tumor involves the coexistence of two histologically distinct neoplasms in one anatomical location. These are rare in the pancreas and are associated with a poor prognosis. We present the first case of an incidentally diagnosed pancreatic collision tumor, consisting of an extraosseous Ewing-like sarcoma and a solid pseudopapillary tumor, in a 43-year-old male. This case emphasizes the diagnostic and therapeutic challenges associated with pancreatic collision tumors. It highlights the necessity of a multidisciplinary approach and adherence to treatment protocols, with a focus on prioritizing treatment based on the more aggressive histology to achieve optimal outcomes.