Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update.

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY
Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Nur Hidayah Reshidan, Nurliyana Ain Abdul Ghani, Azral Ismawy Ahmad, Mohd Saleh Ahmad Kamal, Mohd Aizuddin Mohd Lazaldin, Haryati Ahmad Hairi, Rohimah Mohamud, Nurul Alimah Abdul Nasir
{"title":"Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update.","authors":"Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Nur Hidayah Reshidan, Nurliyana Ain Abdul Ghani, Azral Ismawy Ahmad, Mohd Saleh Ahmad Kamal, Mohd Aizuddin Mohd Lazaldin, Haryati Ahmad Hairi, Rohimah Mohamud, Nurul Alimah Abdul Nasir","doi":"10.1089/jop.2024.0123","DOIUrl":null,"url":null,"abstract":"<p><p>Age-related macular degeneration (AMD) poses a significant threat to visual health among the elderly, necessitating urgent preventive measures as the global population ages. Extensive research has implicated oxidative stress (OS)-induced retinal damage as a primary contributor to AMD pathogenesis, prompting investigations into potential therapeutic interventions. Among the various nutrients studied for their potential in AMD risk reduction, antioxidants have shown promise, with initial findings from the Age-Related Eye Disease Study suggesting a correlation between antioxidant supplementation and decreased AMD progression. This article explores the scientific foundation supporting the therapeutic efficacy of tocotrienol-rich fraction (TRF) as a viable candidate for slowing AMD progression, based on interventional studies. AMD is characterized by OS, inflammation, dysregulated lipid metabolism, and angiogenesis, all of which TRF purportedly addresses through its potent anti-inflammatory, lipid-lowering, antiangiogenic, and antioxidant properties. The review underscores TRF's promising attributes, aiming to deepen understanding of AMD pathogenesis and advocate for TRF-based pharmacological interventions to enhance therapeutic outcomes. Given the pressing need for effective AMD treatments, TRF represents a promising avenue for intervention, offering hope for improved vision outcomes and enhanced quality of life for individuals affected by this debilitating condition.</p>","PeriodicalId":16689,"journal":{"name":"Journal of Ocular Pharmacology and Therapeutics","volume":" ","pages":"150-161"},"PeriodicalIF":1.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ocular Pharmacology and Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/jop.2024.0123","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Age-related macular degeneration (AMD) poses a significant threat to visual health among the elderly, necessitating urgent preventive measures as the global population ages. Extensive research has implicated oxidative stress (OS)-induced retinal damage as a primary contributor to AMD pathogenesis, prompting investigations into potential therapeutic interventions. Among the various nutrients studied for their potential in AMD risk reduction, antioxidants have shown promise, with initial findings from the Age-Related Eye Disease Study suggesting a correlation between antioxidant supplementation and decreased AMD progression. This article explores the scientific foundation supporting the therapeutic efficacy of tocotrienol-rich fraction (TRF) as a viable candidate for slowing AMD progression, based on interventional studies. AMD is characterized by OS, inflammation, dysregulated lipid metabolism, and angiogenesis, all of which TRF purportedly addresses through its potent anti-inflammatory, lipid-lowering, antiangiogenic, and antioxidant properties. The review underscores TRF's promising attributes, aiming to deepen understanding of AMD pathogenesis and advocate for TRF-based pharmacological interventions to enhance therapeutic outcomes. Given the pressing need for effective AMD treatments, TRF represents a promising avenue for intervention, offering hope for improved vision outcomes and enhanced quality of life for individuals affected by this debilitating condition.

年龄相关性黄斑变性的病理生理学和生育三烯醇的治疗潜力:最新进展。
年龄相关性黄斑变性(AMD)对老年人的视觉健康构成重大威胁,随着全球人口老龄化,需要采取紧急预防措施。大量研究表明,氧化应激(OS)诱导的视网膜损伤是AMD发病机制的主要因素,促使研究人员对潜在的治疗干预措施进行研究。在研究其降低AMD风险潜力的各种营养素中,抗氧化剂显示出希望,来自年龄相关眼病研究的初步结果表明,补充抗氧化剂与减少AMD进展之间存在相关性。本文基于介入性研究,探讨了支持富生育三烯醇(TRF)作为减缓AMD进展的可行候选物的治疗效果的科学基础。AMD的特点是OS、炎症、脂质代谢失调和血管生成,TRF通过其有效的抗炎、降脂、抗血管生成和抗氧化特性来解决所有这些问题。这篇综述强调了TRF有希望的属性,旨在加深对AMD发病机制的理解,并倡导基于TRF的药物干预以提高治疗效果。鉴于对AMD有效治疗的迫切需求,TRF代表了一种有希望的干预途径,为受这种衰弱性疾病影响的个人提供了改善视力结果和提高生活质量的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.60
自引率
4.30%
发文量
72
审稿时长
1 months
期刊介绍: Journal of Ocular Pharmacology and Therapeutics is the only peer-reviewed journal that combines the fields of ophthalmology and pharmacology to enable optimal treatment and prevention of ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of therapeutics for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics coverage includes: Glaucoma Cataracts Retinal degeneration Ocular infection, trauma, and toxicology Ocular drug delivery and biotransformation Ocular pharmacotherapy/clinical trials Ocular inflammatory and immune disorders Gene and cell-based therapies Ocular metabolic disorders Ocular ischemia and blood flow Proliferative disorders of the eye Eyes on Drug Discovery - written by Gary D. Novack, PhD, featuring the latest updates on drug and device pipeline developments as well as policy/regulatory changes by the FDA.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信