Identifying healthcare transmission routes of nontuberculous mycobacteria with whole genome sequencing: a systematic review.

IF 3 4区医学 Q2 INFECTIOUS DISEASES

Infection Control and Hospital Epidemiology Pub Date : 2025-02-03 DOI:10.1017/ice.2025.6

Spencer D Schrank, Dale Z Gozum, Elise M Martin, Graham M Snyder

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引用次数: 0

Abstract

Objective: To enumerate and describe the effect of whole genome sequencing (WGS) on epidemiological investigations of healthcare-associated transmission of nontuberculous mycobacteria (NTM).

Design: Systematic review.

Methods: We performed a literature search using targeted search terms to identify articles meeting inclusion criteria. Data extraction of study characteristics and outcomes was performed by two independent researchers. The primary outcome was the author interpretation of WGS utility in the investigation of suspected healthcare-associated transmission of NTM. The secondary outcome was whether a transmission route was identified through WGS.

Results: Thirty-one studies were included in the final analysis with 28 (90%) concluding that WGS was helpful in transmission investigations and in 19 of these 28 (68%) WGS aided in identifying a transmission route. The most common identified transmission routes were water-borne point sources (10), heater-cooler units (6), patient-to-patient (4), and a healthcare worker (1).

Conclusion: WGS is an informative tool in investigating healthcare transmission of NTM.

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用全基因组测序确定非结核分枝杆菌的卫生保健传播途径：一项系统综述。

目的：列举和描述全基因组测序（WGS）在卫生保健相关非结核分枝杆菌（NTM）传播流行病学调查中的作用。设计：系统回顾。方法：我们使用目标检索词进行文献检索，以确定符合纳入标准的文章。研究特征和结果的数据提取由两名独立研究人员进行。主要结果是作者对WGS在疑似NTM卫生保健相关传播调查中的效用的解释。次要结果是是否通过WGS确定了传播途径。结果：31项研究纳入最终分析，其中28项（90%）得出结论认为WGS有助于传播调查，其中19项（68%）WGS有助于确定传播途径。最常见的传播途径是水传播的点源（10）、冷热装置(6)、患者对患者(4)和卫生保健工作者(1)。结论：WGS是调查NTM卫生保健传播的信息工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection Control and Hospital Epidemiology 医学-传染病学

CiteScore

6.40

自引率

6.70%

发文量

289

审稿时长

3-8 weeks

期刊介绍： Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. Written by infection control practitioners and epidemiologists and guided by an editorial board composed of the nation''s leaders in the field, ICHE provides a critical forum for this vital information.