Quality control study of cervical cancer interstitial brachytherapy treatment plans using statistical process control

IF 1.7 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2025-01-31 DOI:10.1016/j.brachy.2024.12.007

Xiao Chen , Xiangxiang Shi , Huaiwen Zhang , Haowen Pang

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引用次数: 0

Abstract

OBJECTIVE

This study explored using statistical process control for quality control of cervical cancer interstitial brachytherapy treatment plans.

MATERIALS AND METHODS

For retrospective analysis, interstitial brachytherapy treatment plans were divided into first (n = 300) and second phases (n = 200). The first phase was chronologically divided 2:1 into training and validation sets. The Dn2cm³ (D2cm³ divided by the high-risk clinical target volume D90) of the organs at risk (the bladder, rectum, and sigmoid colon) were analyzed to draw individual control charts. Process capability analysis charts were drawn, and the statistical process capability was evaluated using the process capability index C_pk. The centerline of the organ at risk dose in the first-phase plan's training set was used as the optimization parameter for the second-phase dataset plan.

RESULTS

The Dn2cm³ centerlines for the bladder, rectum, and sigmoid colon were 0.6980, 0.5440, and 0.4910 in the training set and 0.6845, 0.4528, and 0.4144 in the second phase, respectively. The first-phase δ values were 0.0099, 0.0530, and 0.0268, respectively. The process capability analysis for the first and second phases showed that all indicators had a C_pk >1.

CONCLUSION

For all organs at risk, the Dn2cm³ centerlines were lower in the second phase than in the first phase, indicating that quality control of cervical cancer interstitial brachytherapy treatment plans continuously improved through statistical process control. This method is simple and practical and warrants promotion for application in radiotherapy treatment plan quality control.

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应用统计过程控制对宫颈癌间质性近距离放疗方案的质量控制研究。

目的：探讨应用统计过程控制法对宫颈癌间质性近距离放疗方案进行质量控制。材料与方法：回顾性分析间质性近距离放疗方案分为第一期（n = 300）和第二期（n = 200）。第一阶段按时间顺序2:1分为训练集和验证集。分析危险器官（膀胱、直肠、乙状结肠）的Dn2cm3 (D2cm3除以临床高危靶体积D90)，绘制个体对照图。绘制过程能力分析图，利用过程能力指标Cpk对统计过程能力进行评价。将第一阶段计划训练集中处于危险剂量的器官中心线作为第二阶段数据集计划的优化参数。结果：训练集膀胱、直肠、乙状结肠Dn2cm3中心线分别为0.6980、0.5440、0.4910，二期分别为0.6845、0.4528、0.4144。第一期δ值分别为0.0099、0.0530和0.0268。第一阶段和第二阶段的过程能力分析表明，所有指标都具有Cpk bb1。结论：在所有危险器官中，第二阶段Dn2cm3中心线均低于第一阶段，通过统计过程控制，表明宫颈癌间质性近距离放疗治疗方案的质量控制不断提高。该方法简便实用，在放射治疗计划质量控制中有推广应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.