Unraveling the causal role of sleep traits in development of diabetic retinopathy: A UK Biobank observational study and Mendelian randomization.

Diabetes & vascular disease research Pub Date : 2025-01-01 DOI:10.1177/14791641251318319

Yikeng Huang, Xiaoyin Xu, Xinyu Zhang, Xinyu Zhu, Bo Li, Mingming Ma, Chuandi Zhou, Chufeng Gu, Yujin Jiang, Yanlin Wu, Zhi Zheng, Shuzhi Zhao

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Abstract

Aims: To evaluate the potential causal role of sleep traits (STs) on diabetic retinopathy (DR).

Methods: The cross-sectional study included 23,851 patients with type 2 diabetes from the UK Biobank and used multivariate logistic models to investigate the observational association between STs and DR. Genetic correlation analysis and two-sample Mendelian randomization (MR) were conducted using ST data from the UK Biobank and DR data from the FinnGen consortium to investigate the genetic and causal associations between STs and DR.

Results: Patients who experienced daytime sleepiness often/all of the time had a higher risk for DR (OR: 1.40; 95% CI, 1.09-1.79; p = .008) compared with those who sometimes/never/rarely experienced daytime sleepiness. Genetic correlations between several STs and DR were detected by cross-trait linkage disequilibrium score regression. MR suggested a causal effect of self-reported daytime sleepiness (OR: 4.08; 95% CI, 1.44-11.61; p = .008), and accelerator-derived sleep duration (OR: 0.73; 95% CI, 0.54-0.98; p = .036) and sleep efficiency (OR: 0.54; 95% CI, 0.36-0.80; p = .002) on DR.

Conclusions: STs may have a potential causal role for DR. Attention should be paid to the STs of patients for better prevention and treatment of DR.

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揭示睡眠特征在糖尿病视网膜病变发展中的因果作用：一项英国生物银行观察性研究和孟德尔随机化。

目的：探讨睡眠特征（STs）与糖尿病视网膜病变（DR）的潜在因果关系。方法：横截面研究纳入来自UK Biobank的23,851例2型糖尿病患者，采用多变量logistic模型研究STs与DR之间的观察性关联。使用UK Biobank的ST数据和FinnGen联盟的DR数据，进行遗传相关分析和双样本孟德尔随机化（MR），研究STs与DR之间的遗传和因果关系。经常/一直经历白天嗜睡的患者发生DR的风险更高(OR: 1.40；95% ci, 1.09-1.79；P = .008)，与那些有时/从不/很少经历白天困倦的人相比。通过跨性状连锁不平衡评分回归检测了几种STs与DR之间的遗传相关性。MR表明自我报告的白天嗜睡有因果关系(OR: 4.08；95% ci, 1.44-11.61；p = 0.008)，以及加速器衍生的睡眠持续时间(OR: 0.73；95% ci, 0.54-0.98；p = 0.036)和睡眠效率(OR: 0.54；95% ci, 0.36-0.80；结论：st可能与DR有潜在的因果关系，应引起重视，以更好地预防和治疗DR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diabetes & vascular disease research

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