The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Trials Pub Date : 2025-01-31 DOI:10.1186/s13063-025-08740-x

Kasra Saeedian, Saeed Davaryar, Maryam Emadzadeh, Alireza Akhavan Rezayat

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引用次数: 0

Abstract

Objective: To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy.

Martials and method: This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15-25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05.

Results: A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001).

Conclusion: Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements.

Trial registration: This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.

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补充维生素E对精索静脉曲张切除术患者精子分析的影响：一项三盲随机对照试验。

目的：探讨补充维生素E对精索静脉曲张切除术后精子分析结果的影响。材料和方法：这项单中心、三盲、随机对照试验在伊朗马什哈德的伊玛目礼萨医院进行。90例年龄15-25岁，伴有2级或3级精索静脉曲张的不孕症男性患者随机分为两组。干预组每天服用400单位维生素E，持续3个月，而对照组服用安慰剂。在干预前和干预后3个月分别进行精子分析。采用SPSS version 23进行统计学分析，显著性设置为P。结果：共入组90例患者，随机分为两组，每组45例。平均年龄30.68±6.31岁。干预后，维生素E组精子活力的改善明显高于安慰剂组（P = 0.03）。从干预前到干预后，两组患者的精子活力、数量和形态均有显著改善(P结论：精索静脉曲张切除术后补充维生素E与精子参数的改善有关，提示在精索静脉曲张相关男性不育的治疗中有潜在的益处。然而，单用精索静脉曲张切除术也能显著改善。试验注册：本研究已在伊朗临床试验注册中心注册（IRCT20200911048689N1）。2020年10月10日注册

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trials 医学-医学：研究与实验

CiteScore

3.80

自引率

4.00%

发文量

966

审稿时长

6 months

期刊介绍： Trials is an open access, peer-reviewed, online journal that will encompass all aspects of the performance and findings of randomized controlled trials. Trials will experiment with, and then refine, innovative approaches to improving communication about trials. We are keen to move beyond publishing traditional trial results articles (although these will be included). We believe this represents an exciting opportunity to advance the science and reporting of trials. Prior to 2006, Trials was published as Current Controlled Trials in Cardiovascular Medicine (CCTCVM). All published CCTCVM articles are available via the Trials website and citations to CCTCVM article URLs will continue to be supported.