Centrifuge Siliconization of Primary Container Systems.

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL
Wong Brian, Wang Kaitlin, Kowsari Kavin, Su Yongchao, Forrest William, Givand Jeffrey, Hu Guangli
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引用次数: 0

Abstract

Pre-filled syringes (PFS) have been in use in the pharmaceutical industry for over 60 years. For syringe functionality, a layer of silicone oil is often added as lubrication to promote smooth plunger stopper movement. Importantly, current technologies that generate this silicone oil layer often produce inhomogeneous layers displaying topographical features such as dimples. Additionally, the equipment that generates these layers is generally inaccessible in non-commercial settings. Here, we present a new silicone oil coating technique that addresses the shortcomings of traditional methods to generate a uniform silicone oil layer utilizing commonplace centrifuge technology. Our method creates silicone layers in PFS with improved homogeneity and tunable thickness, ranging from 200 -1400 nm, by adjusting centrifuge speed and temperature.

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来源期刊
CiteScore
7.30
自引率
13.20%
发文量
367
审稿时长
33 days
期刊介绍: The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
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