Imaging Findings Related to Lung Tract Sealant Use in Percutaneous CT-guided Lung Biopsy

IF 3.3 3区医学 Q2 ONCOLOGY

Clinical lung cancer Pub Date : 2025-01-10 DOI:10.1016/j.cllc.2025.01.003

Mohamed M. Soliman , Blake Gershon , Deirdre Sullivan RA , Joanna G. Escalon , Lauren K. Groner , Meghan Cahill , Gulce Askin , Brian W. Sullivan , Bradley B. Pua

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引用次数: 0

Abstract

Purpose

This study examines the imaging findings and malignancy suspicion associated with hydrogel lung tract sealants (h-LTS) used after CT-guided lung biopsy (CTLB).

Materials and Methods

Charts of patients who underwent CTLB from 01/2016 to 01/2020 were reviewed for biopsy date, h-LTS use, resection, and imaging follow-up. Exclusion criteria included resection <3 months postbiopsy, no imaging ≥3 months, and pleural nodules. Postbiopsy imaging was analyzed for abnormalities at the biopsy tract. Out of 164 patients who underwent CTLB with h-LTS, a random subset of 64 patients (Group A) was anonymized and compared with another randomly selected, anonymized group of 64 patients who underwent CTLB without h-LTS during the study period (Group B) to assess inter-reader agreement. Two cardiothoracic radiologists reviewed the anonymized intraprocedural biopsy CT and follow-up imaging at multiple intervals (3-6, 6-12, 12-24, >24months) for abnormalities along the biopsy tract and associated malignancy suspicion (Categories 1-5 [low-high]).

Results

A serpiginous lesion was observed along the biopsy tract in 60% (99/164) of patients who received h-LTS, lasting an average of 23.3 months (Range: 3-67). Moderate inter-reader agreement was seen for abnormalities in Group A patients at all follow-up intervals. FDG-PET/CT showed mild uptake for up to 5 years in 46% of patients. At initial follow-up, 17% of h-LTS scars were rated Category 3 or higher suspicion for malignancy. Most h-LTS scars maintained or decreased in suspicion in later follow-ups.

Conclusion

h-LTS is associated with a serpiginous scar, which may be mildly hypermetabolic and last up to 5 years.

查看原文本刊更多论文

经皮ct引导下肺活检中使用肺道密封剂的影像学表现。

目的：本研究探讨ct引导下肺活检（CTLB）后使用水凝胶肺道密封剂（h-LTS）的影像学表现和恶性怀疑。材料和方法：回顾2016年1月至2020年1月行CTLB的患者的病历，包括活检日期、h-LTS使用、切除和影像学随访。排除标准包括活检道异常及相关恶性肿瘤怀疑（分类1-5[低-高]）切除24个月。结果：60%（99/164）接受h-LTS的患者沿活检道观察到蛇形病变，平均持续23.3个月（范围：3-67）。在所有随访时间间隔中，A组患者的异常情况与读者间一致。FDG-PET/CT显示46%的患者在长达5年的时间里有轻度摄取。在最初的随访中，17%的h-LTS疤痕被评为3类或更高的恶性嫌疑。大多数h-LTS疤痕在后来的随访中保持或减少。结论：h-LTS与蛇形疤痕相关，可能是轻度高代谢，并持续长达5年。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical lung cancer 医学-肿瘤学

CiteScore

7.00

自引率

2.80%

发文量

159

审稿时长

24 days

期刊介绍： Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.