Hsp90: Bringing it all together

IF 3.2 3区 生物学 Q3 CELL BIOLOGY
Georgios Ioannis Karras , Giorgio Colombo , Andrea N. Kravats
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引用次数: 0

Abstract

Heat-shock protein 90 (Hsp90) is an ancient and multifaceted protein-folding machine essential for most organisms. The past 40 years have uncovered remarkable complexity in the regulation and function of Hsp90, which dwarfs most other machines in the cell in sophistication. Here, we propose four analogies to illustrate Hsp90’s sophistication: a multifunctional Swiss Army knife, an automobile engine and its controls, a switchboard acting as a hub and directing signals, and an orchestra conductor setting the tempo of a symphony. Although each of these analogies represents some key Hsp90 activities, none of them captures the entirety of Hsp90’s complexity. Together, these roles enable Hsp90 to support both homeostasis and differentiation, both cellular stability and adaptability. At the 11th International Conference on the Hsp90 Chaperone Machine, the consensus was that to understand this major guardian of proteostasis, we need to study how the many facets of Hsp90’s function influence each other. We hope that these analogies will help to conceptually integrate the many roles of Hsp90 in proteostasis and help the field develop the practical applications of Hsp90 modulators.
Hsp90:把所有的东西放在一起。
热休克蛋白90 (Hsp90)是一种古老的、多方面的蛋白质折叠机器,对大多数生物体至关重要。在过去的40年里,我们已经发现了Hsp90在调控和功能方面的惊人复杂性,这使得细胞中大多数其他机器的复杂性相形见绌。在这里,我们提出了四个类比来说明Hsp90的复杂性:多功能瑞士军刀,汽车发动机及其控制,作为枢纽和指挥信号的交换机,以及为交响乐设定节奏的管弦乐队指挥。尽管这些类比都代表了Hsp90的一些关键活动,但它们都没有反映出Hsp90的全部复杂性。总之,这些作用使Hsp90支持稳态和分化,细胞稳定性和适应性。在第11届Hsp90伴侣机国际会议上,大家一致认为,要了解这一蛋白质平衡的主要守护者,我们需要研究Hsp90功能的许多方面是如何相互影响的。我们希望这些类比将有助于从概念上整合Hsp90在蛋白质静止中的许多作用,并帮助该领域开发Hsp90调节剂的实际应用。
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来源期刊
Cell Stress & Chaperones
Cell Stress & Chaperones 生物-细胞生物学
CiteScore
7.60
自引率
2.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.
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