Efficacy and Safety of Amrubicin Monotherapy After Chemoradiotherapy in Patients With Relapsed Limited Disease Small-cell Lung Cancer.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2025-02-01 DOI:10.21873/anticanres.17461

Akira Matsukida, Hisao Imai, Ayako Shiono, Yasuhiro Ryuno, Kosuke Hashimoto, Y U Miura, Satoshi Endo, Shohei Okazaki, O U Yamaguchi, Atsuto Mouri, Takanori Abe, Kyoichi Kaira, Kunihiko Kobayashi, Shingo Kato, Hiroshi Kagamu

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引用次数: 0

Abstract

Background/aim: Amrubicin is recognized as a second-line treatment for refractory small-cell lung cancer (SCLC) and is administered immediately after chemotherapy; however, it has not been evaluated in patients with recurrent SCLC following chemoradiotherapy (CRT). This study aimed to examine the activity and safety of amrubicin monotherapy in patients with relapsed SCLC previously treated with CRT.

Patients and methods: This retrospective study evaluated patients with relapsed SCLC who had been previously treated with CRT, followed by amrubicin monotherapy between April 2007 and June 2021. The clinical efficacy and toxicity were assessed.

Results: Overall, 30 patients (20 men and 10 women) were enrolled. The response rate was 50.0% [95% confidence interval (CI)=33.1-66.8%]. The median progression-free survival and overall survival from the first amrubicin treatment was 4.1 months (95%CI=2.3-6.0 months) and 13.5 months (95%CI=7.5-16.0 months), respectively. Grade ≥3 hematological adverse events occurred as follows: decreased white blood cells in 63.3% of patients, decreased neutrophil count in 70.0%, and febrile neutropenia in 10.0%. Grade 3 pneumonitis was observed in one patient. No treatment-related deaths occurred.

Conclusion: Amrubicin is both feasible and effective in patients with relapsed SCLC who were previously treated with CRT. The efficacy and toxicity of amrubicin in this study were consistent with those of previous reports, indicating that amrubicin retained its effectiveness post-CRT. Consequently, amrubicin following CRT may be the optimal chemotherapeutic choice for patients with relapsed limited-disease SCLC.

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.