Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2025-02-01 DOI:10.21873/anticanres.17454

Maaret Eskelinen, Tuomas Selander, Jukka Pulkkinen, Kai Kaarniranta, Esa Hämäläinen, Matti Eskelinen

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引用次数: 0

Abstract

Background/aim: The purpose of this work was to assess blood level correlations of free IL-18 (IL-18F) and various cytokines (CYTs), caspase-1 (Casp1), high sensitive C-reactive protein (hs-CRP), and 4-hydroxynonenal (4-HNE) in 56 patients subjected to midline laparotomy (MLa) and to investigate their link to pain scales.

Patients and methods: Blood levels of IL-18F and seven CYTs (IL-18, IL-18BP, IL-1ra, IL-6, IL-8, IL-10, IL-1β), Casp1, hs-CRP, and 4-HNE were measured and the pain surveys were reported using numerical rating scale (NRS) and the Brief Pain Inventory (BPI) scales conducted preoperatively (PRE) and postoperatively (POP).

Results: The IL-18F levels decreased at POP and the decrease between POP1 (immediately after MLa) and POP2 (24 hours after MLa) blood levels (26.5 versus 20.0) was significant (p<0.001). Moreover, the IL-18F levels at POP2 were slightly higher in patients with cancer than in patients with benign disease (21.2 versus 17.8). Interestingly, the IL-18F levels correlated to IL-18 (r=0.523, p<0.001), IL-18BP (r=-0.475, p<0.001), and 4-HNE (r=0.414, p<0.001) levels. Furthermore, the IL-18F levels correlated with BPI score values (r=-0.459, p=0.05).

Conclusion: This is the first report to demonstrate a link between increased IL-18F levels and pain scales in MLa. IL-18F levels decreased significantly after operation and correlated with IL-18, IL-18BP, and 4-HNE blood levels, and inversely correlated with BPI pain scores. These results support the applicability of acute phase response biomarkers in understanding pain in patients subjected to MLa.

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.