Multi-target neural circuit reconstruction and enhancement in spinal cord injury.

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2026-03-01 Epub Date: 2025-01-29 DOI:10.4103/NRR.NRR-D-24-00434
Lingyun Cao, Siyun Chen, Shuping Wang, Ya Zheng, Dongsheng Xu
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引用次数: 0

Abstract

After spinal cord injury, impairment of the sensorimotor circuit can lead to dysfunction in the motor, sensory, proprioceptive, and autonomic nervous systems. Functional recovery is often hindered by constraints on the timing of interventions, combined with the limitations of current methods. To address these challenges, various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury. Notably, neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration, provide neuroprotection, restore neurons, and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract. To improve the effectiveness of these interventions, the implementation of multi-target early interventional neuromodulation strategies, such as electrical and magnetic stimulation, is recommended to enhance functional recovery across different phases of nerve injury. This review concisely outlines the challenges encountered following spinal cord injury, synthesizes existing neurostimulation techniques while emphasizing neuroprotection, repair, and regeneration of impaired connections, and advocates for multi-targeted, task-oriented, and timely interventions.

脊髓损伤中的多靶点神经回路重建与增强。
摘要脊髓损伤后,感觉运动回路损伤可导致运动、感觉、本体感觉和自主神经系统功能障碍。功能恢复常常受到干预时间的限制以及当前方法的局限性的阻碍。为了解决这些挑战,已经开发了各种技术来帮助修复和重建损伤不同阶段的神经回路。值得注意的是,神经调节因其增强神经再生、提供神经保护、恢复神经元以及调节大脑皮层和皮质脊髓束内回路的神经重组的潜力而引起了相当大的关注。为了提高这些干预措施的有效性,建议实施多目标早期介入神经调节策略,如电刺激和磁刺激,以增强神经损伤不同阶段的功能恢复。本文简要概述了脊髓损伤后面临的挑战,综合了现有的神经刺激技术,同时强调神经保护、修复和受损连接的再生,并提倡多目标、任务导向和及时的干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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