Physical Activity Habits and Incident First-Ever Stroke in Middle-Aged Adults-A Prospective Cohort Study.

IF 2.9 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of physical activity & health Pub Date : 2025-01-30 Print Date: 2025-05-01 DOI:10.1123/jpah.2024-0411

Birgit Vahlberg, Eva Ribom, Patrik Wennberg, Stefan Söderberg

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Abstract

Background: Lifestyle affects the risk of cardiovascular events such as myocardial infarction and stroke. Several lifestyle factors, such as physical activity (PA), are modifiable, and in this study, we examined the association between leisure-time PA habits and the risk of a first-ever stroke.

Methods: This prospective study included residents in Västerbotten, Sweden, who participated in the Västerbotten Intervention Programme at 40, 50, and 60 years of age. Altogether, 31,855 individuals (50.5% women, mean age: 42.6 [6.9] y at baseline) participated between 1989 and 2016. Leisure-time PA was categorized as irregular (never/now and then) or regular (once a week/2 or 3 times a week/more than 3 times a week). Changes in PA were compared between examinations (10 y apart). Cases of stroke were validated according to World Health Organization MONICA (Monitoring Trends and Determinants of Cardiovascular Disease) criteria. The risk related to changes in leisure-time PA was estimated using a multivariable Cox regression model.

Results: During an average follow-up of 9.8 years (4.4), 609 incident first-ever stroke cases occurred (1.9%). A multivariable model showed that, compared with individuals with irregular PA at both examinations, those reporting regular PA over time had a lower risk of stroke (hazard ratio: 0.78, 95% CI, 0.61-0.99).

Conclusion: Middle-aged adults who maintained regular PA during their leisure time over 10 years had a lower risk of a first-ever stroke. This association is probably partly mediated by lower body mass index and a reduced risk of hypertension and diabetes.

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一项前瞻性队列研究：中年人的体育活动习惯与首次中风事件的关系

背景：生活方式影响心血管事件如心肌梗死和中风的风险。一些生活方式因素，如体育活动（PA），是可以改变的，在这项研究中，我们研究了休闲时间体育活动习惯与首次中风风险之间的关系。方法：这项前瞻性研究包括瑞典Västerbotten的居民，他们在40岁、50岁和60岁时参加Västerbotten干预计划。在1989年至2016年期间，共有31855人（50.5%为女性，基线时平均年龄为42.6[6.9]岁）参与研究。休闲时间PA分为不定期（从不/偶尔）和定期（每周一次/每周2或3次/每周超过3次）。比较两次检查之间PA的变化（间隔10 y）。中风病例根据世界卫生组织MONICA（心血管疾病监测趋势和决定因素）标准进行验证。使用多变量Cox回归模型估计与休闲时间PA变化相关的风险。结果：在平均随访9.8年（4.4年）期间，发生609例首次卒中（1.9%）。多变量模型显示，与两次检查中PA不规则的个体相比，定期PA的患者卒中风险较低（风险比：0.78,95% CI, 0.61-0.99）。结论：在10年以上的闲暇时间保持定期PA的中年人首次中风的风险较低。这种关联可能部分由较低的身体质量指数和较低的高血压和糖尿病风险介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of physical activity & health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

5.50

自引率

3.20%

发文量

100

期刊介绍： The Journal of Physical Activity and Health (JPAH) publishes original research and review papers examining the relationship between physical activity and health, studying physical activity as an exposure as well as an outcome. As an exposure, the journal publishes articles examining how physical activity influences all aspects of health. As an outcome, the journal invites papers that examine the behavioral, community, and environmental interventions that may affect physical activity on an individual and/or population basis. The JPAH is an interdisciplinary journal published for researchers in fields of chronic disease.