Physiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity.

IF 2.9 4区环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES

Environmental Monitoring and Assessment Pub Date : 2025-01-30 DOI:10.1007/s10661-025-13645-y

Abhishek Kumar, Yogita Thakur, Reshma Sinha

{"title":"Physiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity.","authors":"Abhishek Kumar, Yogita Thakur, Reshma Sinha","doi":"10.1007/s10661-025-13645-y","DOIUrl":null,"url":null,"abstract":"<p><p>Nanoplastic (NP) pollution poses serious health hazards to aquatic ecosystems, impacting various physiological systems of aquatic organisms. This review examines the complex interplay between NPs and different physiological systems. In the digestive system, NPs downregulate the hsp70-like gene in Mytilus galloprovincialis, leading to decreased metabolic processes and impaired digestion. Neural system exposure to NPs induces abnormal expression of genes like neurogenin1, GFAP, FBJ murine osteosarcoma viral oncogene, GAP-43, synapsin IIa, apoptosis regulator a, Bcl2 and Caspase a, and apoptosis-related cysteine peptidase. These genes play a crucial role in neurodevelopment, synaptic function and apoptosis regulation, potentially impacting neurobiology and cancer biology. NPs also affect reproduction, including gametogenesis, spawning, fertilization, embryogenesis and larval survivability. In the respiratory system, treatment with these causes inflammation in the lungs and gills, resulting in respiratory dysfunction. Moreover, this review investigates the complex interaction between NPs and the immune systems of both invertebrates (e.g., molluscs, arthropods, echinoderms) and vertebrates (e.g., zebrafish). NPs-induced alterations in immune cell function heightened the susceptibility to pathogens and disrupted immune signalling pathways. Subcellular inflammatory responses have been characterized by the secretion of inflammation-promoting and chemotactic cytokines such as irg1l, interleukin 1, interferon, interleukin 6, C-C motif chemokine ligand 20a and tumour necrosis factor. The assessment of the combined effects of NPs and other xenobiotics highlighted their possible synergistic impacts on aquatic fauna and the environment. This comprehensive review emphasizes the urgent need for further research to understand the cumulative effects of NPs on organism health and fitness across multiple physiological systems.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 2","pages":"209"},"PeriodicalIF":2.9000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Monitoring and Assessment","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s10661-025-13645-y","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Nanoplastic (NP) pollution poses serious health hazards to aquatic ecosystems, impacting various physiological systems of aquatic organisms. This review examines the complex interplay between NPs and different physiological systems. In the digestive system, NPs downregulate the hsp70-like gene in Mytilus galloprovincialis, leading to decreased metabolic processes and impaired digestion. Neural system exposure to NPs induces abnormal expression of genes like neurogenin1, GFAP, FBJ murine osteosarcoma viral oncogene, GAP-43, synapsin IIa, apoptosis regulator a, Bcl2 and Caspase a, and apoptosis-related cysteine peptidase. These genes play a crucial role in neurodevelopment, synaptic function and apoptosis regulation, potentially impacting neurobiology and cancer biology. NPs also affect reproduction, including gametogenesis, spawning, fertilization, embryogenesis and larval survivability. In the respiratory system, treatment with these causes inflammation in the lungs and gills, resulting in respiratory dysfunction. Moreover, this review investigates the complex interaction between NPs and the immune systems of both invertebrates (e.g., molluscs, arthropods, echinoderms) and vertebrates (e.g., zebrafish). NPs-induced alterations in immune cell function heightened the susceptibility to pathogens and disrupted immune signalling pathways. Subcellular inflammatory responses have been characterized by the secretion of inflammation-promoting and chemotactic cytokines such as irg1l, interleukin 1, interferon, interleukin 6, C-C motif chemokine ligand 20a and tumour necrosis factor. The assessment of the combined effects of NPs and other xenobiotics highlighted their possible synergistic impacts on aquatic fauna and the environment. This comprehensive review emphasizes the urgent need for further research to understand the cumulative effects of NPs on organism health and fitness across multiple physiological systems.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Environmental Monitoring and Assessment 环境科学-环境科学

CiteScore

4.70

自引率

6.70%

发文量

1000

审稿时长

7.3 months

期刊介绍： Environmental Monitoring and Assessment emphasizes technical developments and data arising from environmental monitoring and assessment, the use of scientific principles in the design of monitoring systems at the local, regional and global scales, and the use of monitoring data in assessing the consequences of natural resource management actions and pollution risks to man and the environment.