Polymorphisms in DNA Repair Genes as Biomarkers of Susceptibility for Pesticide-Induced DNA Damage among Agricultural Workers: A Review.

IF 0.8 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Rupinder Kaur, Karashdeep Kaur
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引用次数: 0

Abstract

Pesticides induce oxidative DNA damage and genotoxic effects such as DNA single-strand breaks (SSBs), double-strand breaks (DSBs), DNA adducts, chromosomal aberrations, and enhanced sister chromatid exchanges. Such DNA damage can be repaired by DNA repair mechanisms. In humans, single nucleotide polymorphisms (SNPs) are present in DNA repair genes involved in base excision repair (BER) (OGG1, XRCC1, and APE1), nucleotide excision repair (NER) (XPC, XPD, XPF, XPG, and ERCC1), and double-strand break repair (DSBR) (XRCC4 and RAD51). This systematic review intends to provide information about occupational pesticide exposure, genotoxic effects of pesticides as well as association of DNA repair gene polymorphisms with the risk of pesticide-induced DNA damage. Polymorphisms present in DNA repair genes may influence interindividual variation in DNA repair capacity (DRC) by altering the functional properties of DNA repair enzymes and thus modulate DNA damage. The mechanisms of oxidative damage and disrupted DNA repair caused by the pesticides explain the link between pesticide exposure and adverse health outcomes. These polymorphisms in DNA repair genes could be used as biomarkers of susceptibility for pesticide-induced DNA damage among agricultural workers. It could also be useful as a preventive measure by identifying the genetic susceptibility of agricultural workers to pesticide-induced oxidative stress as well as pesticide poisoning.

DNA修复基因多态性作为农药诱导的农业工人DNA损伤易感性的生物标志物:综述
农药可诱导DNA氧化损伤和基因毒性效应,如DNA单链断裂(SSBs)、双链断裂(DSBs)、DNA加合物、染色体畸变和姐妹染色单体交换增强。这种DNA损伤可以通过DNA修复机制修复。在人类中,参与碱基切除修复(BER) (OGG1、XRCC1和APE1)、核苷酸切除修复(NER) (XPC、XPD、XPF、XPG和ERCC1)和双链断裂修复(DSBR) (XRCC4和RAD51)的DNA修复基因中存在单核苷酸多态性(snp)。本系统综述旨在提供有关农药职业性暴露、农药的遗传毒性效应以及DNA修复基因多态性与农药诱导DNA损伤风险的关系的信息。DNA修复基因中存在的多态性可能通过改变DNA修复酶的功能特性,从而调节DNA损伤,从而影响DNA修复能力(DRC)的个体间变异。农药引起的氧化损伤和DNA修复中断的机制解释了农药暴露与不良健康结果之间的联系。这些DNA修复基因的多态性可以作为农药诱导的农业工人DNA损伤易感性的生物标志物。它还可以作为一种预防措施,通过确定农业工人对农药引起的氧化应激和农药中毒的遗传易感性。
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来源期刊
Indian Journal of Occupational and Environmental Medicine
Indian Journal of Occupational and Environmental Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.60
自引率
0.00%
发文量
25
期刊介绍: The website of Indian Journal of Occupational and Environmental Medicine aims to make the printed version of the journal available to the scientific community on the web. The site is purely for educational purpose of the medical community. The site does not cater to the needs of individual patients and is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her existing physician.
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