Value of Spleen Dynamic Contrast-enhanced Ultrasound Parameters in Predicting Hepatic Vein Pressure Gradient for Patients With Liver Cirrhosis.

IF 2.8 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Tie Zhou, Yan Zhou, Lin Zhao, Yanmin Kan, Jianmin Ding, Cheng Sun, Xiang Jing
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引用次数: 0

Abstract

Goals: To explore dynamic contrast-enhanced ultrasound (CEUS) parameters in predicting hepatic vein pressure gradient (HVPG) for patients with liver cirrhosis (LC).

Background: Noninvasive diagnosis of HVPG remains a challenge.

Study: This prospective study included patients with LC undergoing hepatic vein catheterization and pressure measurement at the hospital from May 2021 to January 2023. The CEUS images (Mindray Resona R9, 1-6-MHz probe frequency; mechanical index=0.08; image depth=10 cm; focus at the lowest point of the diaphragm; dynamic range=70 dB; optimal gain; single SonoVue bolus injection) were taken for 60 seconds after injection and analyzed using VueBox. HVPG (ie, the gold standard for portal hypertension) was measured routinely by catheterization.

Results: Fifty patients with LC were included in the study. The rise time (r=0.6, P<0.01), the fall time (r=0.7, P<0.01), the peak time (r=0.6, P<0.01), wash-in area under the curve (AUC) (r=0.5, P<0.01), the wash-out phase AUC (r=0.4, P<0.01) and wash-in and wash-out phase AUC (r=0.4, P<0.01) of the dynamic spleen CEUS were positively correlated with HVPG. The optimal fall time cutoff levels to predict HVPG ≥10 mm Hg and ≥12 mm Hg were 27.0 and 36.4 seconds, with the AUC being 0.958 and 0.941, respectively. The optimal area under the wash-in area cutoff level to predict HVPG ≥10 mm Hg and ≥12 mm Hg was 1,658,967.38 (a.u) and 4,244,015.90 (a.u), with the AUC being 0.865 and 0.877, respectively.

Conclusions: The fall time and wash-in AUC obtained by dynamic CEUS may help diagnose HVPG in patients with LC without requiring invasive hepatic vein catheterization.

脾动态超声造影参数预测肝硬化患者肝静脉压力梯度的价值。
目的:探讨动态超声造影(CEUS)参数对肝硬化(LC)患者肝静脉压力梯度(HVPG)的预测价值。背景:HVPG的无创诊断仍然是一个挑战。研究:这项前瞻性研究纳入了2021年5月至2023年1月在医院接受肝静脉置管和压力测量的LC患者。超声造影图像(minray Resona R9,探头频率1-6 mhz;机械指数= 0.08;图像深度=10 cm;聚焦于横膈膜的最低点;动态范围=70 dB;最优增益;注射后60秒取单次索诺维丸,用VueBox进行分析。HVPG(即门脉高压的金标准)通过导管常规测量。结果:50例LC患者纳入研究。结论:动态超声造影获得的下降时间和冲洗AUC可以帮助LC患者诊断HVPG,而无需侵入性肝静脉置管。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of clinical gastroenterology
Journal of clinical gastroenterology 医学-胃肠肝病学
CiteScore
5.60
自引率
3.40%
发文量
339
审稿时长
3-8 weeks
期刊介绍: Journal of Clinical Gastroenterology gathers the world''s latest, most relevant clinical studies and reviews, case reports, and technical expertise in a single source. Regular features include cutting-edge, peer-reviewed articles and clinical reviews that put the latest research and development into the context of your practice. Also included are biographies, focused organ reviews, practice management, and therapeutic recommendations.
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