Prevalence and risk factors for skeletal muscle mass loss in individuals with type 1 diabetes.

IF 1.2 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2024-10-30 eCollection Date: 2025-01-01 DOI:10.1007/s13340-024-00770-1

Kanako Shimura, Junnosuke Miura, Zhuo Shen, Takuya Asanuma, Satoshi Takagi, Sari Hoshina, Hiroko Takaike, Yasuko Uchigata, Tetsuya Babazono

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Abstract

This study aimed to the investigate prevalence and factors associated with reduced skeletal muscle mass in non-elderly adults with type 1 diabetes (T1D). Ninety-nine patients (65 women, mean age: 43 ± 11 years, range 20-65 years) with acute-onset T1D who underwent body component analysis between October 2016 and April 2018 were studied. Bioelectrical impedance analysis was used to calculate the skeletal muscle mass index (SMI) of the limbs. A multivariate logistic regression analysis was employed to identify factors related to SMI reduction. Seventeen participants (17.1%) exhibited decreased SMI. There were no significant differences in sex, age, or HbA1c between the low and normal SMI groups. The prevalence of diabetic retinopathy was 58.8% in the low SMI group, which was significantly higher than that in the normal SMI group (15.9%; p < 0.05). The duration of T1D was significantly longer in the low SMI group (25.6 ± 11.3 years) than that in the normal SMI group (20.0 ± 10.0 years, p < 0.04). Multivariate logistic regression analysis revealed that retinopathy, male sex, and body mass index were independent risk factors for low SMI (all p < 0.05). Thus, the factors associated with decreased skeletal muscle mass in non-elderly adult patients with T1D were identified.

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1型糖尿病患者骨骼肌质量损失的患病率及危险因素

本研究旨在调查非老年1型糖尿病（T1D）患者骨骼肌量减少的患病率及相关因素。研究了2016年10月至2018年4月期间接受体成分分析的99例急性发作T1D患者（65例女性，平均年龄：43±11岁，范围20-65岁）。采用生物电阻抗分析法计算四肢骨骼肌质量指数（SMI）。采用多变量logistic回归分析确定与重度精神分裂症减少相关的因素。17名参与者（17.1%）表现出SMI下降。低SMI组和正常SMI组在性别、年龄或HbA1c方面没有显著差异。低SMI组糖尿病视网膜病变患病率为58.8%，显著高于正常SMI组(15.9%；p

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.